应用基因工程技术增强间充质干细胞移植效果
发布时间：2018-07-23 17:31
【摘要】：间充质干细胞(MSCs)在再生医学领域应用前景无限。它取材较容易,无论是天然的还是通过细胞工程诱导获得的均具有多向分化能力。成功的MSCs治疗依赖于有效的细胞输送和移植细胞的长期存活,以便能长久地在目标位点更多地发挥效应。在MSCs移植前应用基因工程技术对其进行修饰可取得这一效果。本文介绍了能提高移植MSCs的迁移能力、防止MSCs衰老和凋亡及提高MSCs存活率的基因工程方法策略。
[Abstract]:Mesenchymal stem cell (MSCs) has a promising future in the field of regenerative medicine. It is easy to draw materials, both natural and induced by cell engineering have multi-directional differentiation ability. Successful MSCs therapy depends on effective cell delivery and long term survival of transplanted cells so that more effects can be exerted at the target sites for a long time. This effect can be achieved by modifying MSCs with genetic engineering before transplantation. This paper introduces genetic engineering strategies that can improve the migration ability of transplanted MSCs, prevent MSCs aging and apoptosis, and improve MSCs survival rate.
【作者单位】： 华中科技大学同济医学院附属荆州医院药学部;
【分类号】：R457.7
本文编号：2140126
[Abstract]:Mesenchymal stem cell (MSCs) has a promising future in the field of regenerative medicine. It is easy to draw materials, both natural and induced by cell engineering have multi-directional differentiation ability. Successful MSCs therapy depends on effective cell delivery and long term survival of transplanted cells so that more effects can be exerted at the target sites for a long time. This effect can be achieved by modifying MSCs with genetic engineering before transplantation. This paper introduces genetic engineering strategies that can improve the migration ability of transplanted MSCs, prevent MSCs aging and apoptosis, and improve MSCs survival rate.
【作者单位】： 华中科技大学同济医学院附属荆州医院药学部;
【分类号】：R457.7
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