磷酸酶Wip1基因敲除表型及机制研究进展

发布时间：2018-08-09 12:47

【摘要】：野生型p53诱导的磷酸酶1(Wild-type p53-induced phosphatase1,Wip1)是PP2C(The type 2Cfamily of protein phosphatases)磷酸酶家族中的一员。在DNA损伤修复中起重要作用,并作为原癌基因受到越来越多的关注。Wip1敲除小鼠虽然能够存活,但寿命缩短,并出现多系统异常,包括生殖系统、免疫体系、内分泌系统、神经系统等,具体表现:雄性生殖器官萎缩及雄性不育、对病原体敏感、T细胞和B细胞功能受损、胰岛素抵抗、体重增长受限、脂肪量减少、焦虑和抑郁样行为增加等。相关机制研究发现,Wip1通过去磷酸化不同蛋白底物而在多种生理和病理过程中发挥重要作用。本文旨在对小鼠Wip1基因缺失所致表型及其初步的分子机制进行综述,为进一步研究Wip1的生物学功能以及哺乳动物体内生理和病理过程的发生机制提供参考。
[Abstract]:Wild-type p53-induced phosphatase 1 (Wip1) induced by wild type p53 is a member of PP2C (The type 2Cfamily of protein phosphatases) phosphatase family. Wip1 knockout mice, which play an important role in the repair of DNA damage, have received more and more attention as proto-oncogenes. Although Wip1 knockout mice can survive, their lifespan is shortened, and multiple system abnormalities occur, including reproductive system, immune system, endocrine system. Nervous system, specific manifestations: male reproductive organ atrophy and male sterility, sensitive to pathogens T cell and B cell function damage, insulin resistance, body weight growth limited, decreased fat, anxiety and depression like behavior increase. It has been found that Wip1 plays an important role in many physiological and pathological processes by dephosphorylation of different protein substrates. The aim of this paper is to review the phenotypes and molecular mechanisms of Wip1 gene deletion in mice, and to provide references for further study on the biological functions of Wip1 and the mechanism of physiological and pathological processes in mammals.
【作者单位】：中国农业科学院北京畜牧兽医研究所;
【基金】：国家自然科学基金(31572378) 农业部中央级公益性科研院所基本科研业务费项目(2016ywf-yb-4)
【分类号】：S852.3

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