新疆维吾尔族与汉族NSCLC患者血清EGFR基因突变及临床特征分析

发布时间：2018-08-24 08:10

【摘要】：目的表皮生长因子受体(epidermal growth factor receptor,EGFR)抑制剂对非小细胞肺癌(non-small cell lung cancer,NSCLC)EGFR基因突变患者有很好的疗效,因此EGFR基因突变状态对治疗方案的选择意义重大。新疆作为多民族聚集地,维吾尔族和汉族在基因、遗传方面存在差异,本研究主要探讨新疆地区汉族及维吾尔族初诊NSCLC患者血清EGFR突变差异及其与临床特征的关系。方法选取2015-05-01-2016-08-30石河子大学医学院第一附属医院(65例)和喀什地区第一人民医院(51例)初次诊治的非小细胞肺癌患者116例,其中汉族70例,维吾尔族46例。采用二代测序法对患者进行血清EGFR突变检测,统计两组突变差异并分析其临床特征。结果汉族NSCLC血清EGFR突变率27.1%(19/70),维吾尔族NSCLC血清EGFR突变率8.7%(4/46),差异有统计学意义,χ~2=5.942,P=0.015。汉族腺癌突变率36.5%(19/52)高于维吾尔族腺癌突变率13.3%(4/30),差异有统计学意义,χ~2=5.076,P=0.024。两者突变均以19、21外显子突变为主,差异无统计学意义,P=0.406。临床特征比较,汉族中女性、腺癌、不吸烟患者突变率较高,差异有统计学意义,P0.05。维吾尔族中腺癌突变率较高,其它如年龄、临床分期、淋巴结转移情况等在汉族或维吾尔族中差异无统计学意义,P0.05。Logistic多因素分析显示,种族是EGFR基因突变的独立影响因素,P0.05,95%CI为0.145~1.599。而性别、年龄、是否吸烟和临床分析对EGFR突变影响不显著。结论新疆维吾尔族和汉族血清EGFR突变与种族有关,与外显子类型、临床特征无明显关联。
[Abstract]:Objective Epidermal growth factor receptor (epidermal growth factor receptor,EGFR) inhibitor has a good therapeutic effect on patients with EGFR gene mutation in non-small cell lung cancer (non-small cell lung cancer,NSCLC). As a multi-ethnic gathering place, there are differences in gene and heredity between Uygur and Han nationality in Xinjiang. This study mainly discusses the difference of serum EGFR mutation and its relationship with clinical characteristics in newly diagnosed NSCLC patients of Han nationality and Uygur nationality in Xinjiang region. Methods 116 patients with non-small cell lung cancer (NSCLC) were selected from the first affiliated Hospital of Shihezi University Medical College (65 cases) and the first people's Hospital of Kashgar region (51 cases) from 2015-05-01-2016-08-30, including 70 cases of Han nationality and 46 cases of Uygur nationality. The second generation sequencing method was used to detect the EGFR mutation in serum of the patients. The differences between the two groups were analyzed and the clinical characteristics were analyzed. Results the mutation rate of serum EGFR in NSCLC of Han nationality was 27.1% (19 / 70), and that of NSCLC in Uygur was 8.7% (4 / 46). The difference was statistically significant (蠂 ~ (2 / 2) 5.942). The mutation rate of adenocarcinoma of Han nationality was 36.5% (19 / 52) higher than that of Uygur adenocarcinoma 13.3% (4 / 30). The main mutation of the two mutations was exon 19, and the difference was not statistically significant (P < 0. 406). The clinical characteristics of Han women, adenocarcinoma, non-smoking patients with a higher mutation rate, the difference was statistically significant (P 0.05). The mutation rate of adenocarcinoma was higher in Uygur nationality. There was no significant difference in age, clinical stage and lymph node metastasis between Uygur nationality and Han nationality (P 0.05). Logistic multivariate analysis showed that race was the independent factor of EGFR gene mutation. Sex, age, smoking and clinical analysis had no significant effect on EGFR mutation. Conclusion Serum EGFR mutation in Xinjiang Uygur and Han nationality is related to race, not to exon type and clinical features.
【作者单位】：石河子大学医学院第一附属医院肿瘤内科;喀什地区第一人民医院肿瘤内科;
【基金】：国家自然科学基金(81560381) 石河子大学重大科技攻关计划(gxjs2013-zdgg07)
【分类号】：R734.2

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