OSAHS患者TNF-α水平及锌指蛋白36基因多态性研究

发布时间：2018-08-29 17:57

【摘要】：目的:分析OSAHS与肿瘤坏死因子(TNF)-α及锌指蛋白36(ZFP36)基因多态性的相关性。方法:以204例OSAHS患者为研究组,同时选取同期97例健康体检者作为对照组。通过TaqMan-PCR方法对2组的ZFP36位点(rs17879933、rs3746083、rs251864)进行检测,采用放射免疫法对TNF-α及其他生化指标进行检测,采用Monet32导系统监测记录所有入选者夜间睡眠呼吸相关指标。结果:研究组TNF-α、总胆固醇、血尿酸、舒张压、收缩压、BMI、腹围以及颈围均显著高于对照组(P0.05)。研究组与对照组在ZFP36rs251864与rs17879933位点的基因型及等位基因频率分布差异有统计学意义(P0.05)。rs251864GG及rs17879933Ⅱ基因型患者的腹围、BMI、TNF-α、三酰甘油(TG)水平均明显高于同一位点的其他2个基因型(P0.05)。ZFP36的3个位点不同基因型间所有的睡眠呼吸监测指标均差异无统计学意义(P0.05)。Logistic回归分析结果表明,在对性别、年龄等一系列因素予以控制后,未发现ZFP36的3个位点基因多态性与OSAHS之间存在相关性。结论:ZFP36可能是通过调节TNF-α等炎症因子及干预代谢参与OSAHS的发病进程,ZFP36的3个位点的突变不是OSAHS发生的独立危险因素。
[Abstract]:Aim: to investigate the association of OSAHS with tumor necrosis factor (TNF)-伪 and zinc finger protein 36 (ZFP36) gene polymorphism. Methods: 204 patients with OSAHS were selected as study group and 97 healthy persons as control group. The ZFP36 locus (rs17879933,rs3746083,rs251864) was detected by TaqMan-PCR method, TNF- 伪 and other biochemical indexes were detected by radioimmunoassay, and the nocturnal sleep-related indexes were recorded by Monet32 guide system. Results: the levels of TNF- 伪, total cholesterol, uric acid, diastolic blood pressure, systolic blood pressure, abdominal circumference and neck circumference in the study group were significantly higher than those in the control group (P0.05). The genotype and allele frequency distribution of ZFP36rs251864 and rs17879933 loci in the study group and the control group were significantly different (P0.05). Rs251864GG and rs17879933 鈪，

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