心律调节基因与抗心律失常中药靶标研究进展

发布时间：2018-09-08 11:35

【摘要】：心律失常是心血管疾病中一类重要的疾病,严重威胁着人类的健康。抗心律失常药物多为离子通道阻滞剂,存在效率低的特点,并伴随严重的副作用。因此,对药物作用机制的深入研究并发展新的治疗策略,成为抗心律失常药物研究的新热点。后基因组学加速了对基因突变、基因多态性、基因表达量变化及表观遗传学改变的理解和认识,它们在心律失常的发生和发展过程中同样起着重要作用。而传统中药在治疗心律失常方面因其疗效显著、副作用少等优势,受到越来越多的关注。就目前与心律失常相关的基因及其对应疾病进行概述,并从中药复方及其有效成分调节异常表达基因的角度,对现有中药抗心律失常的可能靶点进行总结。以期为中药抗心律失常药理学研究提供借鉴。
[Abstract]:Arrhythmia is one of the most important diseases in cardiovascular diseases, which is a serious threat to human health. Antiarrhythmic drugs are ion channel blockers with low efficiency and severe side effects. Therefore, the further study on the mechanism of drug action and the development of new therapeutic strategies have become a new hotspot in the research of antiarrhythmic drugs. Post-genomics accelerates the understanding of gene mutations, gene polymorphisms, changes in gene expression and epigenetic changes, which also play an important role in the occurrence and development of arrhythmias. Traditional Chinese medicine has attracted more and more attention in treating arrhythmia because of its remarkable curative effect and less side effects. The genes related to arrhythmia and their corresponding diseases are summarized. The possible targets of Chinese herbal medicine against arrhythmia are summarized from the point of view of the regulation of abnormal expression genes by Chinese herbal compound and its effective components. In order to provide reference for the pharmacological study of antiarrhythmia of traditional Chinese medicine.
【作者单位】：天津中医药大学天津市现代中药国家重点实验室;天津国际生物医药联合研究院中药新药研发中心;
【基金】：国家自然科学基金资助项目(81274128) 科技部国家国际合作专项(2013DFA31620)
【分类号】：R259

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