新疆和田长寿地区维吾尔族人群ACE基因多态性与生活方式的交互作用

发布时间：2018-09-11 08:45

【摘要】：目的:探讨血管紧张素转换酶(ACE)基因插入/缺失(I/D)多态性与生活方式在新疆和田地区维吾尔族人群长寿现象发生中的交互作用。方法:采用调查表与实验室研究分别对长寿组与对照组进行问卷调查与ACE基因分型,应用Logistic回归模型分析新疆和田地区维吾尔族人长寿发生的生活方式因素,并进一步根据交互作用系数(γ,γ=β_(eg)/β_e),判断ACE基因型与生活方式之间是否存在交互作用。结果:ACE基因的ID+DD基因型是和田人长寿的促进因素,巴旦木(OR=2.096,γ=2.564)、核桃(OR=2.026,γ=1.772)、运动(OR=1.802,γ=2.902)、吸烟(OR=0.426,γ=0.621)等4项生活方式因素与ACE基因多态性间存在一定的交互作用。玫瑰酱、肉类食品与和田人长寿现象无关(P0.05)。结论:长寿现象是环境及遗传因素综合作用的结果。巴旦木、核桃、运动等因素对新疆维吾尔族人群长寿现象有放大作用,正向交互作用,吸烟有减弱作用,负向交互作用。
[Abstract]:Objective: to investigate the interaction between angiotensin converting enzyme (ACE) gene insertion / deletion (I / D) polymorphism and lifestyle in Uygur population in Hotan area Xinjiang. Methods: questionnaire survey and ACE genotyping were carried out in longevity group and control group, and Logistic regression model was used to analyze the lifestyle factors of Uygur people in Hotan area of Xinjiang. Furthermore, according to the interaction coefficient (纬, 纬 = 尾 _ (eg) / 尾 -population), the interaction between ACE genotype and lifestyle was determined. Results the ID DD genotype of the 1: ACE gene was the promoting factor for the longevity of Hetian people. There was some interaction between the ACE gene polymorphism and the four lifestyle factors (OR=2.096, 纬 2.564), walnut (OR=2.026, 纬 1.772), exercise (OR=1.802, 纬 2.902), smoking (OR=0.426, 纬 0.621). Rose sauce and meat food were not related to the longevity of Hotan people (P0.05). Conclusion: longevity is the result of environmental and genetic factors. The factors such as Badan, walnut and exercise had a magnifying effect on the longevity of Uygur population in Xinjiang, positive interaction, weakened smoking and negative interaction.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R161.7

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