珠江口3种鲸豚的MHC-I基因多态性研究
发布时间：2018-09-13 07:50
【摘要】：旨在了解珠江口栖息的中华白海豚(Sousa chinensis)、宽脊江豚(Neophocaena phocaenoides)和点斑原海豚(Stenella attenuate)免疫相关基因MHC-I(Major Histocompatibility Complex)的多态性及其表达情况,以期为这3种鲸豚的保育工作提供基础资料。通过克隆测序的方法,首次证实MHC-I基因在这3种鲸豚体内表达。选择压力分析,表明MHC-I基因在这3种鲸豚中均受到强烈的正选择作用,提示其具有重要的免疫功能。3种鲸豚的MHC-I基因在系统发育树上相互混杂在一起,表明MHC-I基因存在跨物种多态性。结合选择压力分析和跨物种多态性,发现MHC-I基因受到平衡选择作用。珠江口3种鲸豚MHC-I基因多态性可能由平衡选择维持。
[Abstract]:The aim of this study was to investigate the polymorphisms and expression of the immune-related genes MHC-I (Major Histocompatibility Complex) in the Chinese white dolphins (Sousa chinensis), Neophocaena phocaenoides and Stenella attenuate inhabiting the Pearl River Estuary, and to provide basic information for the conservation of the three species of cetaceans. Sequence analysis showed that MHC-I gene was strongly positive in all three species of cetaceans, suggesting that MHC-I gene had important immune function. Mixed MHC-I genes were found in phylogenetic trees of three species of cetaceans, suggesting that MHC-I gene was polymorphic across species. Combining selection stress analysis and cross-species polymorphism, we found that MHC-I gene was affected by balanced selection. The MHC-I gene polymorphism of three species of whales in the Pearl River Estuary may be maintained by balanced selection.
【作者单位】： 南海生物资源开发与利用协同创新中心;广东省海洋资源与近岸工程重点实验室;珠海市海洋生物资源与环境重点实验室;中山大学海洋科学学院;
【基金】：国家自然科学基金项目(41276147,41576128) 农业部中华白海豚保护行动计划(2015); 香港海洋公园保育基金(2013)~~
【分类号】：Q953
本文编号：2240524
[Abstract]:The aim of this study was to investigate the polymorphisms and expression of the immune-related genes MHC-I (Major Histocompatibility Complex) in the Chinese white dolphins (Sousa chinensis), Neophocaena phocaenoides and Stenella attenuate inhabiting the Pearl River Estuary, and to provide basic information for the conservation of the three species of cetaceans. Sequence analysis showed that MHC-I gene was strongly positive in all three species of cetaceans, suggesting that MHC-I gene had important immune function. Mixed MHC-I genes were found in phylogenetic trees of three species of cetaceans, suggesting that MHC-I gene was polymorphic across species. Combining selection stress analysis and cross-species polymorphism, we found that MHC-I gene was affected by balanced selection. The MHC-I gene polymorphism of three species of whales in the Pearl River Estuary may be maintained by balanced selection.
【作者单位】： 南海生物资源开发与利用协同创新中心;广东省海洋资源与近岸工程重点实验室;珠海市海洋生物资源与环境重点实验室;中山大学海洋科学学院;
【基金】：国家自然科学基金项目(41276147,41576128) 农业部中华白海豚保护行动计划(2015); 香港海洋公园保育基金(2013)~~
【分类号】：Q953
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