基质金属蛋白酶-3和Ⅰ型胶原α1链基因多态性对原发性冻结肩易感性的影响

发布时间：2018-09-18 15:10

【摘要】：目的目前原发性冻结肩的病因及发病机制在基因及分子生物学领域的研究报道较少。文中旨在探讨基质金属蛋白酶-3(MMP-3)和I型胶原α1链(COL1A1)基因多态性对原发性冻结肩的易感性的影响。方法选择2016年1月至6月来南京军区南京总医院骨科就诊的42名原发性冻结肩患者为病例组,50名健康受试者作为对照组。对所有研究对象的MMP-3基因多态性rs679620及rs522616与COL1A1基因多态性rs1107946,分别进行基因型测定。结果 MMP-3多态性位点rs679620基因型分布与原发性冻结肩易感性无明显相关性(P0.05)。等位基因A与G比较,差异有统计学意义(OR=0.54,95%CI:0.30~0.99,P=0.044)。COL1A1多态性位点rs1107946基因型及等位基因频率与原发性冻结肩易感性无明显相关性(P=0.994、0.920)。与隐性遗传模型GG相比,GT、TT和GT+TT差异无统计学意义;等位基因T与G比较,差异无统计学意义(P0.05)。结论 MMP-3基因多态性rs679620等位基因A是原发性冻结肩发病的保护性因素。MMP-3基因多态性rs522616和COL1A1基因多态性rs1107946与原发性冻结肩易感性无关。
[Abstract]:Objective there are few reports on the etiology and pathogenesis of primary frozen shoulder in the field of gene and molecular biology. The aim of this study was to investigate the effects of matrix metalloproteinase-3 (MMP-3) and type I collagen 伪 1 chain (COL1A1) gene polymorphisms on susceptibility to primary frozen shoulder. Methods from January to June 2016, 42 patients with primary frozen shoulder who came to the orthopedic department of Nanjing General Hospital of Nanjing military region were selected as the control group and 50 healthy subjects as the control group. Genotypes of MMP-3 gene polymorphism rs679620 and rs522616 and COL1A1 gene polymorphism rs1107946, were determined in all subjects. Results there was no significant correlation between the distribution of rs679620 genotypes at MMP-3 polymorphism loci and the susceptibility to primary frozen shoulder (P0.05). There was no significant correlation between rs1107946 genotype and allele frequency of allele A and G (OR=0.54,95%CI:0.30~0.99,P=0.044. COL1A1 polymorphism) and susceptibility to primary frozen shoulder (P0. 994 / 0. 920). Compared with recessive genetic model (GG), there was no significant difference in TT and GT TT, and there was no significant difference in allele T and G (P0.05). Conclusion Polymorphic rs679620 allele A of MMP-3 gene is the protective factor of primary frozen shoulder. MMP-3 gene polymorphism rs522616 and COL1A1 gene polymorphism rs1107946 are not associated with primary frozen shoulder susceptibility.
【作者单位】：南方医科大学金陵医院(南京军区南京总医院)骨科;南京医科大学护理学院;
【基金】：江苏省临床医学科技专项基金(BL2012002)
【分类号】：R686

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