雌激素受体α基因甲基化与骨质疏松关系的研究进展
发布时间：2018-09-19 20:52
【摘要】：妇女绝经后体内雌激素水平显著下降,发生骨质疏松和骨折的风险显著增加。DNA甲基化作为表观遗传作用机制之一,与骨质疏松的发生有着重要关系。雌激素受体α基因甲基化水平升高会抑制雌激素受体α基因的表达,进而影响骨的新陈代谢,但具体作用机制有待于进一步研究。这种甲基化的状态是可以逆转的,通过干预基因甲基化,可以影响骨形成和骨重吸收的过程,进而为诊断和治疗骨质疏松提供新的思路。研究显示血清同型半胱氨酸(Hcy)会影响雌激素受体α基因甲基化水平,绝经后妇女平均血清Hcy浓度显著高于绝经前妇女,提示血清Hcy浓度可以作为早期筛查骨质疏松的指标之一;葛根素达到合适浓度后可抑制成骨细胞雌激素受体α基因甲基化,增强细胞ERαmRNA表达,进而促使成骨细胞增殖分化,从而用于骨质疏松的治疗。通过分析阐明雌激素受体α基因甲基化与骨质疏松的关系,可以早期筛选骨质疏松的高危人群,更简便快捷地诊断骨质疏松,为临床进行基因诊断提供理论依据;可以选择性地开发调节雌激素受体α基因甲基化药物,从而使治疗骨质疏松的靶向性更强,为骨质疏松的基因治疗提供理论依据。
[Abstract]:Estrogen level in postmenopausal women decreased significantly, and the risk of osteoporosis and fracture increased significantly. DNA methylation was one of the epigenetic mechanisms, and had an important relationship with the occurrence of osteoporosis. The increase of methylation level of estrogen receptor 伪 gene will inhibit the expression of estrogen receptor 伪 gene and then affect the metabolism of bone, but the specific mechanism needs to be further studied. This state of methylation can be reversed by intervening gene methylation, which can affect the process of bone formation and bone resorption, thus providing a new idea for the diagnosis and treatment of osteoporosis. The results showed that serum homocysteine (Hcy) could affect the methylation level of estrogen receptor 伪 gene. The average serum Hcy concentration in postmenopausal women was significantly higher than that in premenopausal women, suggesting that serum Hcy concentration could be used as an index for early screening of osteoporosis. Puerarin can inhibit the methylation of estrogen receptor 伪 gene, enhance the expression of ER 伪 mRNA in osteoblasts, and promote the proliferation and differentiation of osteoblasts, which can be used in the treatment of osteoporosis. By analyzing and clarifying the relationship between estrogen receptor 伪 gene methylation and osteoporosis, the high risk population of osteoporosis can be screened early, and the diagnosis of osteoporosis is easier and faster, which provides theoretical basis for clinical gene diagnosis. The methylation drugs regulating estrogen receptor 伪 gene can be selectively developed, which makes the targeted treatment of osteoporosis stronger, and provides theoretical basis for gene therapy of osteoporosis.
【作者单位】： 广州中医药大学第三临床医学院;广州中医药大学第三附属医院;海南省中医院;广州中医药大学第一临床医学院;广州市荔湾区骨伤科医院;深圳市宝安区中医院;
【基金】：国家自然科学基金(81373654) 广东省自然科学基金(2015A030313351)
【分类号】：R580
[Abstract]:Estrogen level in postmenopausal women decreased significantly, and the risk of osteoporosis and fracture increased significantly. DNA methylation was one of the epigenetic mechanisms, and had an important relationship with the occurrence of osteoporosis. The increase of methylation level of estrogen receptor 伪 gene will inhibit the expression of estrogen receptor 伪 gene and then affect the metabolism of bone, but the specific mechanism needs to be further studied. This state of methylation can be reversed by intervening gene methylation, which can affect the process of bone formation and bone resorption, thus providing a new idea for the diagnosis and treatment of osteoporosis. The results showed that serum homocysteine (Hcy) could affect the methylation level of estrogen receptor 伪 gene. The average serum Hcy concentration in postmenopausal women was significantly higher than that in premenopausal women, suggesting that serum Hcy concentration could be used as an index for early screening of osteoporosis. Puerarin can inhibit the methylation of estrogen receptor 伪 gene, enhance the expression of ER 伪 mRNA in osteoblasts, and promote the proliferation and differentiation of osteoblasts, which can be used in the treatment of osteoporosis. By analyzing and clarifying the relationship between estrogen receptor 伪 gene methylation and osteoporosis, the high risk population of osteoporosis can be screened early, and the diagnosis of osteoporosis is easier and faster, which provides theoretical basis for clinical gene diagnosis. The methylation drugs regulating estrogen receptor 伪 gene can be selectively developed, which makes the targeted treatment of osteoporosis stronger, and provides theoretical basis for gene therapy of osteoporosis.
【作者单位】： 广州中医药大学第三临床医学院;广州中医药大学第三附属医院;海南省中医院;广州中医药大学第一临床医学院;广州市荔湾区骨伤科医院;深圳市宝安区中医院;
【基金】：国家自然科学基金(81373654) 广东省自然科学基金(2015A030313351)
【分类号】：R580
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