凋亡抑制基因Livin和Survivin在食管癌中表达及其与胸腔镜下根治术疗效的相关性

发布时间：2018-10-12 16:30

【摘要】：目的探讨凋亡抑制基因Livin和Survivin在食管癌中表达与胸腔镜下根治术疗效的相关性。方法该行胸腔镜根治术治疗的食管癌患者50例,采用免疫组织化学法检测其食管癌组织和癌旁组织中凋亡抑制基因Livin和Survivin的表达,根据凋亡抑制基因Livin和Survivin表达情况分析其与患者胸腔镜下根治术远处转移率、复发率、5年生存率的关系。结果癌组织凋亡抑制基因Livin和Survivin表达阳性率高于正常的癌旁组织(P0.05);有远处转移患者的两基因表达阳性率高于无远处转移患者,有复发患者的两基因表达阳性率高于无复发患者,≤5年生存率患者的两基因表达阳性率高于5年的患者(P0.05);凋亡抑制基因Livin和Survivin两者联合评价食管癌患者胸腔镜下根治术疗效敏感性、特异性及准确性均高于两基因单独评价(P0.05)。结论凋亡抑制基因Livin和Survivin在食管癌中高表达,其与远处转移、复发及患者5年生存率有关,凋亡抑制基因Livin和Survivin阴性表达者术后疗效较良好且对术后疗效判断具有较高的敏感性、准确性及特异性。
[Abstract]:Objective to investigate the relationship between the expression of Livin and Survivin in esophageal carcinoma and the curative effect of thoracoscopic radical surgery. Methods 50 patients with esophageal carcinoma treated by thoracoscopic radical operation were examined for the expression of apoptosis suppressor gene Livin and Survivin in esophageal carcinoma and adjacent tissues by immunohistochemical method. According to the expression of apoptosis suppressor gene Livin and Survivin, the relationship between the expression of apoptosis suppressor gene and the distant metastasis rate, recurrence rate and 5-year survival rate of patients undergoing thoracoscopic radical surgery was analyzed. Results the positive rate of Livin and Survivin expression in cancer tissues was higher than that in normal tissues (P0.05), the positive rate of Livin and Survivin in patients with distant metastasis was higher than that in patients without distant metastasis, and the positive rate of expression of two genes in patients with recurrence was higher than that in patients without recurrence. The positive rate of expression of two genes in patients with 鈮，

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