MiRNA-146a基因多态性与肝癌易感性的Meta分析

发布时间：2018-11-11 10:18

【摘要】：目的有研究报道,miRNA-146ars2910164位点基因多态性与肝癌患病风险之间存在相关性,但部分在线发表的研究结果对此存在争议。本文的研究目的在于总体评价肝癌易感性与miRNA-146ars2910164基因多态性与之间的相关性。方法我们系统地检索PubMed,Embase,Web of Science,中国知网以及中国生物医学文献数据库2017年1月30日之前发表的旨在探讨miRNA-146a rs2910164基因多态性与肝癌易感性的病例对照研究。结果本文共纳入了 18项病例对照研究,包括5657例肝癌病例与6680例健康对照。在总体和亚组分析中我们用总的比值比(oddratio,OR)及相应的95%可信区间(credibility interval,CI)来评价两者的相关性。总体统计结果显示,miRNA-146ars2910164位点的基因多态性与肝癌的易感性在等位基因模型(C vs G:OR =0.96,95%CI=0.88-1.06)、杂合子模型(GC vs GG:OR = 0.98,95%CI=0.88-1.09)、纯合子模型(CC vs GG:OR =0.90,95%CI = 0.74-1.09)、显性模型(GC/CC vs GG:OR = 0.95,95%CI = 0.82-1.10)及隐性模型(CC vs GC/GG:OR = 0.95,95%CI= 0.84-1.07)中均未发现相关性。结论本研究表明,目前尚没有足够的证据能够证明miRNA-146ars2910164位点的基因多态性是肝癌发病的危险因素。因此,为进一步明确该基因位点与肝癌发病易感性的相关性,有必要开展包含更大样本量及更多种族的研究。
[Abstract]:Objective to study the association between miRNA-146ars2910164 locus polymorphism and the risk of liver cancer, but some online published results are controversial. The purpose of this study was to evaluate the association between susceptibility to liver cancer and polymorphism of miRNA-146ars2910164 gene. Methods We systematically searched the PubMed,Embase,Web of Science, China knowledge Network and the Chinese Biomedical Literature Database published before January 30, 2017 to explore the miRNA-146a rs2910164 gene polymorphism and susceptibility to liver cancer in a case-control study. Results A total of 18 case-control studies were conducted, including 5657 liver cancer cases and 6680 healthy controls. The total ratio (oddratio,OR) and the corresponding 95% confidence interval (credibility interval,CI) were used to evaluate the correlation between the two groups in population and subgroup analysis. The total statistical results showed that the polymorphism of miRNA-146ars2910164 locus was associated with the susceptibility of HCC in allelic model (C vs G:OR = 0.9695 (0.88-1.06). Heterozygote model (GC vs GG:OR = 0.98-1.09), homozygote model (CC vs GG:OR = 0.90,95CI = 0.74-1.09), There was no correlation between the dominant model (GC/CC vs GG:OR = 0.95-95 CI = 0.82-1.10) and the recessive model (CC vs GC/GG:OR = 0.95-95 CI = 0.84-1.07). Conclusion this study shows that there is not enough evidence to prove that miRNA-146ars2910164 gene polymorphism is a risk factor for HCC. Therefore, in order to further understand the relationship between the gene locus and susceptibility to liver cancer, it is necessary to carry out a study involving a larger sample size and more races.
【学位授予单位】：南京医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.7

【相似文献】