单核细胞趋化蛋白-1基因多态性与癌易感性的Meta分析

发布时间：2019-01-05 20:36

【摘要】：探讨单核细胞趋化蛋白-1(MCP-1)2518 A/G基因多态性与癌易感性的关联情况。计算机检索相关数据库,收集自建库至2016年12月国内外已发表的有关MCP-1-2518 A/G基因多态性与肿瘤易感性关联的研究。共纳入30项病例对照研究(包括5 602例患癌患者和6 500例健康对照人群)。采用Stata 12.0软件进行统计学分析。Cochran Q检验和I2检验对各研究进行异质性检验,计算合并比值比(OR值)及其95%可信区间(95%CI)以评价关联性,Begg's test和Egger's test评估发表偏倚,并进行Meta回归、敏感性分析。Meta分析结果提示MCP-1-2518 A/G多态性与癌患病风险无明显相关性。但根据肿瘤类型的亚组分析发现,MCP-1基因多态性与肝癌、乳腺癌、卵巢癌和非小细胞肺癌的发病风险显著相关(p0.05)。根据种族进行的亚组分析发现,携GG基因型的白种人群患癌风险增加(GG vs.AG/AA:OR=1.81,95%CI=1.10~2.96),而MCP-1-2518 A/G多态性与亚洲人群患癌风险无相关性(p0.05)。多态性与癌易感性的关联在基于对照组来源、研究样本量和低质量研究的亚组分析中显著,而根据对照组是否符合HWE遗传平衡和基因检测方法的亚组分析,这种关系不显著。Meta回归分析表明,种族差异和纳入研究的质量可能是各研究间异质性存在的主要来源。综上所述,MCP-1-2518 A/G多态性可能与癌易感性相关,GG基因型可增加白种人群患癌风险,MCP-1基因A2518G位点有望作为癌早期诊断和预后判定的重要分子标志物。
[Abstract]:To investigate the association between 2518 A / G polymorphism of monocyte chemoattractant protein-1 (MCP-1) and cancer susceptibility. The related databases were searched by computer, and the published studies on the association of MCP-1-2518 A / R G gene polymorphism with tumor susceptibility were collected from the self-built database up to December 2016 at home and abroad. A total of 30 case-control studies were conducted (including 5 602 cancer patients and 6 500 healthy controls). Stata 12.0 software was used for statistical analysis,. Cochran Q test and I2 test were used to test the heterogeneity of each study. The combined ratio (OR) and its 95% confidence interval (95%CI) were calculated to evaluate the correlation. Begg's test and Egger's test were used to evaluate publication bias, Meta regression and sensitivity analysis. The results of Meta analysis showed that there was no significant correlation between MCP-1-2518 A / G polymorphism and cancer risk. However, according to the subgroup analysis of tumor types, MCP-1 gene polymorphism was significantly associated with the risk of liver cancer, breast cancer, ovarian cancer and non-small cell lung cancer (p0.05). Subgroup analysis based on race found that white people with GG genotype had an increased risk of cancer (GG vs.AG/AA:OR=1.81,95%CI=1.10~2.96). There was no correlation between the MCP-1-2518 A / G polymorphism and the risk of cancer in Asian population (p0.05). The association between polymorphism and susceptibility to cancer was significant in subgroup analysis based on control group origin, sample size and low quality studies, and subgroup analysis based on HWE genetic balance and gene detection methods in the control group. The Meta regression analysis showed that racial differences and the quality of the included studies may be the main sources of heterogeneity among the studies. In conclusion, MCP-1-2518 A / G polymorphism may be associated with cancer susceptibility, and GG genotype may increase the risk of cancer in white race population. The A2518G locus of MCP-1 gene may be an important molecular marker for early diagnosis and prognosis of cancer.
【作者单位】：重庆医科大学附属第一医院
【基金】：重庆市卫生计生委医学科研重点项目(20141001)资助
【分类号】：R730.2

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