pre-miR-27a基因rs895819多态性与大肠癌易感性的Meta分析

发布时间：2019-03-05 07:42

【摘要】：目的近年来,有关pre-miR-27a基因rs895819位点多态性与大肠癌易感性关系的研究日益增多,但结论并不一致。本研究从循证医学角度,综合评价pre-miR-27a基因rs895819位点多态性与大肠癌易感性的关系。方法通过检索数据库PubMed、Cochrane Library、EMBASE以及中国知网数据库、万方数据库,收集有关pre-miR-27a基因rs895819位点多态性与大肠癌罹患风险关系的病例-对照研究。检索时间1998-01-01-2015-11-01。依据文献纳入及排除标准筛选相关文献,提取基本数据信息并进行文献质量评估。采用Stata 12.0软件行Meta分析,计算合并OR值和95%CI,并进一步行亚组分析和敏感性分析。结果最终纳入6个病例-对照研究(包括2 025例大肠癌患者和2 320例非肿瘤对照者)。Meta分析结果显示,pre-miR-27a基因rs895819多态性与大肠癌罹患风险具有显著的相关性,Gvs A:OR=1.18,95%CI=1.08~1.30;GG vs AA/AG:OR=1.52,95%CI=1.26~1.97;GG vs AA:OR=1.53,95%CI=1.26~1.86,P值均0.05。亚组分析结果发现,亚洲人群也有相似的结论,Gvs A:OR=1.21,95%CI=1.09~1.35;AG/GGvs AA:OR=1.15,95%CI=1.00~1.32;GG vs AA/AG:OR=1.57,95%CI=1.27~1.93;GG vs AA:OR=1.59,95%CI=1.27~1.98,P值均0.05。结论 pre-miR-27a基因rs895819多态性与大肠癌易感性之间具有相关性,并且GG基因型具有增加罹患大肠癌的风险。
[Abstract]:Aim in recent years, the relationship between rs895819 polymorphism of pre-miR-27a gene and susceptibility to colorectal cancer is increasing, but the conclusions are not consistent. In this study, we evaluated the relationship between rs895819 polymorphism of pre-miR-27a gene and susceptibility to colorectal cancer from the point of view of evidence-based medicine. Methods A case-control study on the relationship between rs895819 polymorphism of pre-miR-27a gene and the risk of colorectal cancer was carried out by searching PubMed,Cochrane Library,EMBASE database, China knowledge website database and Wanfang database. Search time 1998 / 01 / 2015 / 11 / 01. According to the criteria of literature inclusion and exclusion, the relevant documents were screened, the basic data information was extracted and the literature quality was evaluated. The combined OR value and 95% CI were calculated by Meta analysis with Stata 12.0 software, and further subgroup analysis and sensitivity analysis were performed. Results six case-control studies (including 2 025 colorectal cancer patients and 2 320 non-tumor controls) were included. Meta-analysis showed that there was a significant correlation between pre-miR-27a gene rs895819 polymorphism and colorectal cancer risk. Gvs A / OR 1.18, 95% CI 1.08 / 1.30; The GG vs AA/AG:OR=1.52,95%CI=1.26~1.97;GG vs AA:OR=1.53,95%CI=1.26~1.86, P values were 0.05. The results of subgroup analysis showed that there were similar conclusions in Asian population, Gvs A / A OR 1.21, 95% CI 1.09 / 1.35 AG / GGvs AA:OR=1.15,95%CI=1.00~1.32;GG vs AA/AG:OR=1.57,95%CI=1.27~1.93; The GG vs AA:OR=1.59,95%CI=1.27~1.98, P values were 0.05. Conclusion rs895819 polymorphism of pre-miR-27a gene is associated with susceptibility to colorectal cancer, and GG genotype may increase the risk of colorectal cancer.
【作者单位】：南昌大学第二附属医院胃肠外科;永丰县人民医院普外一科;
【基金】：南昌大学研究生创新基金(cx2015168)
【分类号】：R735.34

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