谷胱甘肽转移酶T1位点基因多态性与中国人群肺癌易感性的Meta分析

发布时间：2019-07-04 09:43

【摘要】：目的用Meta分析的方法定量评价谷胱甘肽转移酶(GST)T1位点基因多态性与中国人群肺癌易感性的相关性。方法计算机检索EMBASE、Pub Med、Cochrane Library、中国生物医学文献数据库、相关期刊论文、中文科技期刊数据库以及万方数据库,收集GSTT1位点基因多态性与中国人群肺癌易感性的病例对照试验。以病例组和对照组GSTT1基因位点基因型分布的比值比(OR)为疗效测量指标,采用STATA10.0软件进行统计分析。结果最终纳入19篇病例对照研究进行Meta分析,病例组共纳入肺癌患者2 356例,对照组共纳入健康志愿者3 260例。Meta分析结果显示:CSTT1基因功能型和缺失型在肺癌的发生率方面差异有统计学意义[OR=1.27,95%CI(1.06~1.52)]。结论 GSTT1基因缺失型可能增加了中国人群患肺癌的易感性。
[Abstract]:Objective to quantitatively evaluate the relationship between (GST) T1 gene polymorphism and lung cancer susceptibility in Chinese population by Meta analysis. Methods the EMBASE,Pub Med,Cochrane Library, Chinese Biomedical Literature Database, Chinese Journal full-text Database, Chinese Sci-tech Journal Database and Wanfang Database were searched by computer. The case-control trials of GSTT1 locus gene polymorphism and lung cancer susceptibility in Chinese population were collected. The ratio of genotypic distribution of GSTT1 gene locus to (OR) in case group and control group was used as therapeutic effect measurement index, and STATA10.0 software was used for statistical analysis. Results Meta analysis was performed in 19 case-control studies. A total of 2356 patients with lung cancer were included in the case group and 3260 healthy volunteers in the control group. Meta-analysis showed that there was significant difference in the incidence of lung cancer between CSTT1 gene functional type and deletion type [OR=1.27,95%CI (1.06 鈮，

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