基于数据挖掘技术分析中药治疗慢性乙型病毒性肝炎用药规律的研究
发布时间：2018-07-14 15:15
【摘要】：目的:通过搜集在中国期刊网全文数据库公开发表的关于慢性乙型病毒性肝炎的相关文章,采用IBM SPSS20.0数据挖掘软件作为挖掘工具,探索慢性乙型病毒性肝炎的用药规律。方法:以设定好的关键词为检索条件收集中国期刊网全文数据库(CNKI)中公开发表的治疗慢性乙型病毒性肝炎的相关文献,依据纳入标准与排除标准,建立方剂数据库,对方剂中的中药规范化处理后,建立中药原始数据库,运用IBM SPSS20.0软件进行数据挖掘,总结药物的四性、五味、归经、用药频次的规律,方剂涉及的证候分布规律,聚类分析得到新的高频药物组合。结果:四性统计中居于第一位的是“寒”,五味统计中居于第一位的是“苦”,归经统计中居于第一位的是“肝经”,方剂证候统计中居于第一位的是“肝郁脾虚证”,高频药物的归类中前两位是清热类与补虚类中药,聚类分析挖掘药物组合(2味中药)10个、高频药物组合(2味中药)6个。结论:运用数据挖掘技术探索慢性乙型肝炎的中医药治疗用药的基本规律:现代中医药治疗慢性乙型病毒性肝炎的药物的使用四性与五味以苦寒、甘温类中药为主;药物归经以肝经、脾经、胃经、肾经为主,说明慢乙肝的治疗主要以三脏为主,可以反推出慢乙肝的病变部位主要在于肝脏;涉及中药方剂的证候以肝郁脾虚、瘀血阻络等虚实夹杂病证为主;药物的使用频次归类,以清热类与补虚类为多;聚类分析得到高频药物组合若干,这些高频药物组合能够针对慢乙肝的主要致病因子“湿、热、毒、痰、虚、瘀”等起到特定的治疗作用,为临床慢性乙型肝炎的辨证治疗提供辨证思路及组方思维,为新药的研发提供参考。
[Abstract]:Objective: to explore the rule of drug use of chronic viral hepatitis B by using IBM SPSS 20.0 data mining software through collecting related articles published in the full text database of Chinese Journal Network. Methods: according to the criteria of inclusion and exclusion, the Chinese Journal Network Full-text Database (CNKI) was used to collect the literature on the treatment of chronic viral hepatitis B (CHB), and the database of prescriptions was established according to the criteria of inclusion and exclusion. After standardized treatment of traditional Chinese medicine in prescription, the original database of traditional Chinese medicine was established, and the data mining was carried out by using IBM SPSS 20.0 software. The four properties, five flavors, return to the classics, the regularity of the frequency of medication, and the distribution law of syndromes involved in the prescription were summarized. A new high-frequency drug combination was obtained by cluster analysis. Results: among the four sex statistics, the "cold" is the first, the "bitter" is the first in the five-flavor statistics, the "liver classics" is the first in the statistics of returning to the classics, and the first in the syndrome statistics of prescription is "liver depression and spleen deficiency syndrome". In the classification of high frequency drugs, the first two are clearing heat and tonifying deficiency. Cluster analysis excavates 10 drug combinations (2 Chinese medicines) and 6 high frequency drugs combinations (2 kinds of traditional Chinese medicines). Conclusion: using data mining technology to explore the basic law of traditional Chinese medicine in treating chronic hepatitis B: the four and five kinds of drugs used in the treatment of chronic hepatitis B are mainly bitter cold and sweet and warm Chinese medicine. The main drugs are liver Meridian, spleen Meridian, stomach Meridian and Kidney Meridian, indicating that the treatment of chronic Hepatitis B mainly consists of three viscera, and the pathological position of CHB can be inferred mainly from the liver; the syndromes related to traditional Chinese medicine prescription are liver stagnation and spleen deficiency. Blood stasis and blockage of collaterals and so on are the main types of diseases with deficiency and deficiency; the use frequency of drugs is classified into the categories of clearing heat and tonifying deficiency; cluster analysis shows several combinations of high frequency drugs, which can be aimed at the main pathogenic factors of chronic hepatitis B, namely, wetness, heat, etc. Poison, phlegm, deficiency and stasis "play a special role in treating chronic hepatitis B, and provide dialectical thinking and prescription thinking for clinical treatment of chronic hepatitis B, and provide reference for the research and development of new drugs."
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;TP311.13
本文编号：2122059
[Abstract]:Objective: to explore the rule of drug use of chronic viral hepatitis B by using IBM SPSS 20.0 data mining software through collecting related articles published in the full text database of Chinese Journal Network. Methods: according to the criteria of inclusion and exclusion, the Chinese Journal Network Full-text Database (CNKI) was used to collect the literature on the treatment of chronic viral hepatitis B (CHB), and the database of prescriptions was established according to the criteria of inclusion and exclusion. After standardized treatment of traditional Chinese medicine in prescription, the original database of traditional Chinese medicine was established, and the data mining was carried out by using IBM SPSS 20.0 software. The four properties, five flavors, return to the classics, the regularity of the frequency of medication, and the distribution law of syndromes involved in the prescription were summarized. A new high-frequency drug combination was obtained by cluster analysis. Results: among the four sex statistics, the "cold" is the first, the "bitter" is the first in the five-flavor statistics, the "liver classics" is the first in the statistics of returning to the classics, and the first in the syndrome statistics of prescription is "liver depression and spleen deficiency syndrome". In the classification of high frequency drugs, the first two are clearing heat and tonifying deficiency. Cluster analysis excavates 10 drug combinations (2 Chinese medicines) and 6 high frequency drugs combinations (2 kinds of traditional Chinese medicines). Conclusion: using data mining technology to explore the basic law of traditional Chinese medicine in treating chronic hepatitis B: the four and five kinds of drugs used in the treatment of chronic hepatitis B are mainly bitter cold and sweet and warm Chinese medicine. The main drugs are liver Meridian, spleen Meridian, stomach Meridian and Kidney Meridian, indicating that the treatment of chronic Hepatitis B mainly consists of three viscera, and the pathological position of CHB can be inferred mainly from the liver; the syndromes related to traditional Chinese medicine prescription are liver stagnation and spleen deficiency. Blood stasis and blockage of collaterals and so on are the main types of diseases with deficiency and deficiency; the use frequency of drugs is classified into the categories of clearing heat and tonifying deficiency; cluster analysis shows several combinations of high frequency drugs, which can be aimed at the main pathogenic factors of chronic hepatitis B, namely, wetness, heat, etc. Poison, phlegm, deficiency and stasis "play a special role in treating chronic hepatitis B, and provide dialectical thinking and prescription thinking for clinical treatment of chronic hepatitis B, and provide reference for the research and development of new drugs."
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259;TP311.13
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