奈西雅预防化疗呕吐有效性的Meta分析

发布时间：2018-06-10 20:47

本文选题：奈西雅 + 药物疗法　；参考：《中国全科医学》2009年24期

【摘要】：目的评价奈西雅预防化疗呕吐的临床效果。方法采用电子数据库PubMed、Spring、Ovid,中国生物医学数据库(CBM)、中文期刊全文数据库(CNKI)、Google搜索引擎,检索词包括"奈西雅/雷莫司琼","胃肠道反应/副作用/紊乱","化疗";"nasea/ramosetron","gastrointestinal reaction/side effects/disturbance","chemotherapy",搜索试验组为奈西雅(盐酸雷莫司琼),对照组为格拉司琼或昂丹司琼等预防化疗引起胃肠道反应的随机对照试验和临床对照试验。提取的数据采用RevMan4.2软件进行Meta分析。结果纳入文献21篇共1965例,其中各研究具有同质性(χ2=24.54,P0.05),可以进行合并分析,采用固定效应模型分析,结果显示24h内奈西雅组对化疗药物呕吐的有效率高于对照组(P0.01)。结论奈西雅预防化疗药物呕吐的有效率优于其他止吐药物,受纳入文献数量和质量的限制,本次Meta分析结果尚有待于高质量的大样本随机对照试验予以证实。
[Abstract]:Objective to evaluate the clinical effect of Naisai's prevention of chemotherapeutic vomiting. Methods the electronic database PubMed, Spring, Ovid, Chinese biomedical database (CBM), Chinese journal full text database (CNKI) and Google search engine were used. The retrieval words included "naisya / reuisetron", "gastrointestinal reaction / side effect / disorder", "chemotherapy", "nasea/ramosetron", "Gastroin". Testinal reaction/side effects/disturbance "," "chemotherapy", the search test group was Naisai (HCl Si Qiong), and the control group was a randomized controlled trial and a clinical controlled trial for GI reaction caused by granisetron or ondansetron. The data extracted were analyzed by RevMan4.2 software for Meta analysis. The results were included in the literature 21. A total of 1965 cases, of which the study was homogeneity (x 2=24.54, P0.05), can be combined and analyzed with the fixed effect model analysis. The results showed that the effectiveness of 24h Nai naxya group was higher than the control group (P0.01). Conclusion Nai Xi Ya is more effective than other antiemetic drugs. The results of this Meta analysis still need to be confirmed by high quality large sample randomized controlled trials.
【作者单位】：天津中医药大学附属第二医院;中国医科大学附属第一医院护理部;
【基金】：辽宁省科学技术厅项目(2008225010-3)
【分类号】：R730.5

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