浑浊介质中近红外漫反射光谱测量灵敏度解析
发布时间：2019-01-08 09:26
【摘要】：在采用近红外漫反射光谱对浑浊介质中的物质浓度做定量分析时,物质浓度测量的灵敏度与所选的光源-检测器位置有较大的关联。解析了物质浓度测量的灵敏度随光源-检测器距离变化的曲线特点,给出了三个特殊位置:灵敏度全局极大位置、灵敏度为零的位置和灵敏度局部极大的位置。以葡萄糖在某浑浊介质溶液(含血红蛋白、白蛋白的Intralipid溶液)中的测量为例,从扩散方程、蒙特卡罗模拟、漫反射光谱测量实验三方面,均验证了灵敏度曲线中存在的这三个特殊位置。另一方面,考虑到近红外光源的稳定性、铟镓砷检测器的量子效率与系统噪声等因素的限制,采用仪器的信噪比作为另一个客观指标,对实际测量可得到的灵敏度进行了评价。综合灵敏度曲线的特点和仪器的实际测量水平,给出了测量葡萄糖的最佳位置,可实现最优的测量灵敏度与测量精度。采用优化后的测量位置,葡萄糖的测量灵敏度可提高10倍以上。测量葡萄糖灵敏度的研究对人体组织中的无创血糖检测有较好的参考价值,同时,对漫射光谱灵敏度的解析方法可被借鉴于其他物质的近红外漫反射光谱测量位置的优选。
[Abstract]:In the quantitative analysis of the mass concentration in turbid media by near infrared diffuse reflectance spectroscopy, the sensitivity of the material concentration measurement is closely related to the position of the selected light source and detector. In this paper, the characteristics of the curve of the sensitivity of the material concentration measurement with the distance between the light source and the detector are analyzed, and three special positions are given: the global maximum position of sensitivity, the position of zero sensitivity and the position of local maximum sensitivity. Taking the measurement of glucose in a turbid medium solution (Intralipid solution containing hemoglobin and albumin) as an example, the diffusion equation, Monte Carlo simulation and diffuse reflectance spectrum measurement experiments were studied. These three special positions in the sensitivity curve are verified. On the other hand, considering the stability of near infrared light source, quantum efficiency of indium gallium arsenic detector and system noise, the SNR of the instrument is used as another objective index to evaluate the sensitivity obtained from the actual measurement. Based on the characteristics of the sensitivity curve and the actual measurement level of the instrument, the optimum position of glucose measurement is given, which can achieve the optimal measurement sensitivity and accuracy. The sensitivity of glucose measurement can be increased by more than 10 times by using the optimized measuring position. The study of glucose sensitivity has a good reference value for noninvasive blood glucose detection in human tissues. At the same time, the analytical method of diffuse spectral sensitivity can be used for reference to select the location of other substances in near-infrared diffuse reflectance spectroscopy measurement.
【作者单位】： 天津大学精密测试技术及仪器国家重点实验室;
【基金】：国家863计划(2012AA022602,2012YQ090194) 国家自然科学基金(60938002,81471698)
【分类号】：O433.1
本文编号：2404413
[Abstract]:In the quantitative analysis of the mass concentration in turbid media by near infrared diffuse reflectance spectroscopy, the sensitivity of the material concentration measurement is closely related to the position of the selected light source and detector. In this paper, the characteristics of the curve of the sensitivity of the material concentration measurement with the distance between the light source and the detector are analyzed, and three special positions are given: the global maximum position of sensitivity, the position of zero sensitivity and the position of local maximum sensitivity. Taking the measurement of glucose in a turbid medium solution (Intralipid solution containing hemoglobin and albumin) as an example, the diffusion equation, Monte Carlo simulation and diffuse reflectance spectrum measurement experiments were studied. These three special positions in the sensitivity curve are verified. On the other hand, considering the stability of near infrared light source, quantum efficiency of indium gallium arsenic detector and system noise, the SNR of the instrument is used as another objective index to evaluate the sensitivity obtained from the actual measurement. Based on the characteristics of the sensitivity curve and the actual measurement level of the instrument, the optimum position of glucose measurement is given, which can achieve the optimal measurement sensitivity and accuracy. The sensitivity of glucose measurement can be increased by more than 10 times by using the optimized measuring position. The study of glucose sensitivity has a good reference value for noninvasive blood glucose detection in human tissues. At the same time, the analytical method of diffuse spectral sensitivity can be used for reference to select the location of other substances in near-infrared diffuse reflectance spectroscopy measurement.
【作者单位】： 天津大学精密测试技术及仪器国家重点实验室;
【基金】：国家863计划(2012AA022602,2012YQ090194) 国家自然科学基金(60938002,81471698)
【分类号】：O433.1
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