广州地区输血传播登革病毒风险研究

发布时间：2018-01-06 17:34

本文关键词：广州地区输血传播登革病毒风险研究　出处：《广东医学》2017年07期 　论文类型：期刊论文

【摘要】：目的评估登革热疫情爆发期间登革病毒(DENV)在广州地区输血传播的风险以及对血液安全的影响。方法采用随机抽样的方法抽取在广州地区参加献血的无偿献血者4 000名,检测其血清中DENV IgM抗体以及IgM结果阳性者进一步检测DENV RNA,并对他们的性别和年龄特征进行分析。结果检出DENV IgM抗体阳性标本131份,阳性率为3.28%。其中男82例,女49例,阳性率分别为3.11%、3.58%,不同性别间阳性率差异无统计学意义(醊2=0.63,P=0.43);18~20岁、21~30岁、31~40岁、41~50岁以及51~60岁年龄组抗DENV IgM抗体阳性率分别为2.68%、3.85%、3.27%、2.79%和3.38%,年龄组间差异无统计学意义(醊2=3.07,P=0.55)。131例DENV IgM阳性献血者中检出DENV RNA阳性2例,阳性率为0.05%,DENV-1型和DENV-2型各1例。结论在DENV流行期间,广州地区献血人群中通过输血传播DENV存在一定的风险,通过输血传播病原体的风险应当引起重视。
[Abstract]:Objective to evaluate dengue virus (DENVV) during dengue fever outbreak. The risk of blood transfusion transmission and its influence on blood safety in Guangzhou area. Methods A random sampling method was used to select 4 000 blood donors who participated in blood donation in Guangzhou area. The DENV IgM antibody in the serum and the positive result of IgM in the serum of the patients were further detected for DENV RNA. Their sex and age characteristics were analyzed. Results 131 DENV IgM antibody positive specimens were detected, the positive rate was 3.28.The positive rate was 82 males and 49 females. The positive rates were 3.11% and 3.58%, respectively. There was no significant difference in the positive rates between different genders (P < 0.43). The positive rates of anti DENV IgM antibody were 2.68% and 3.85% respectively in the age group of 1820 years old, 30 years old and 30 years old, 40 years old, 41 years old and 50 years old and 51 years old, 60 years old, respectively, and the positive rates of anti DENV IgM antibody were 2.68% and 3.85%, respectively. 3.27% 2.79% and 3.38%, there was no significant difference among the age groups (2 / 3. 07). The positive rate of DENV RNA was 0.05% in 2 out of 0.05% DENV IgM positive blood donors. Conclusion during the period of DENV epidemic, there is a certain risk of transmission of DENV by blood transfusion among blood donors in Guangzhou. The risk of transmission of pathogens through blood transfusion should be taken seriously.
【作者单位】：广州血液中心体检采血部;广州血液中心临床输血研究所;广州血液中心贮血发血部;广州血液中心质量控制部;
【基金】：广东省医学科研基金立项项目(编号:B2015041) 广州市卫生和计划生育科技一般引导项目(编号:20161A010072)
【分类号】：R457.1;R512.8
【正文快照】： 血液安全已被世界卫生组织(WHO)列为全球卫生重点工作之一,世界各国对保障血液安全工作都十分重视,特别是很多国家根据不同病毒的流行情况将不同的病原体列入献血者的筛查范围,如西尼罗病毒(West Nile virus,WNV)和人类T淋巴细胞白血病病毒(HTLV)。据WHO估算,全球100多个国家

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