丰富环境对小鼠缺血性脑损伤后运动、社交功能的作用

发布时间：2018-01-07 04:22

本文关键词：丰富环境对小鼠缺血性脑损伤后运动、社交功能的作用　出处：《中国康复理论与实践》2017年01期 　论文类型：期刊论文

【摘要】：目的研究长期丰富环境对促进小鼠缺血性脑损伤后运动、社交功能恢复的作用。方法成年雄性ICR小鼠16只,复制大脑中动脉永久性栓塞模型。术后第1天将小鼠分为丰富环境组(n=8)和标准环境组(n=8)。术后7 d、14 d、21 d、28 d对小鼠进行改良神经损害严重程度评分(m NSS),进行疲劳转棒仪、聪明笼子检测。结果术后28 d,丰富环境组m NSS评分与转棒疲劳试验结果优于标准环境组(t2.927,P0.05)。一般运动试验中,术后14~28 d,丰富环境组在聪明笼子中间区域出现的时间长于标准环境组(t2.480,P0.05);社交行为试验中,术后7~28 d,丰富环境组比标准环境组表现出对陌生小鼠更感兴趣的趋势,但无显著性差异(P0.05);术后14~28 d,丰富环境组出现在中间区域的时间明显长于标准环境组(t3.472,P0.01);术后14 d在聪明笼子中的移动速度高于标准环境组(P0.05)。结论丰富环境有助于小鼠缺血性脑损伤后运动功能恢复,并可能促进其社交功能恢复。
[Abstract]:Objective to study the long-term enriched environment to promote ischemic brain injury in mice after exercise, social function recovery. Methods 16 adult male ICR mice, replication of permanent middle cerebral artery embolism model. After first days the mice were divided into enriched environment group (n=8) and standard environment group (n =8) 7 d after the operation. 14, D, 21 d, 28 d mice underwent modified neurological severity score (m, NSS) of rotarod instrument, intelligent detection cage. Results after the operation of 28 d, m enriched environment group NSS score test results of fatigue and the rotating rod is superior to the standard environment group (t2.927, P0.05). The general exercise test in D, 14~28 after the operation, the enriched environment group is longer than the standard environmental group in the middle area of smart cage emergence time (t2.480, P0.05); social behavior test, after 7~28 D, EE group than standard environmental group showed the unfamiliar mice are more interested in the trend, but no significant difference (P0.05 14~28 d); after the operation, rich environment group was significantly longer than the standard environment group in the middle region of the time (t3.472, P0.01); after 14 d in the smart cage in moving speed is higher than the standard environment group (P0.05). Conclusion the rich environment contributes to ischemic brain injury in mice after the recovery of motor function, and may promote the recovery of social function.

【作者单位】：上海交通大学附属第一人民医院康复医学科;上海交通大学医学院附属瑞金医院康复医学科;上海交通大学Med-X研究院;
【基金】：上海市科委产学研医项目(No.11DZl921307)
【分类号】：R743.3;R493
【正文快照】： 脑卒中是一种由脑供血障碍导致的急性综合征,其中约80%为供血受阻导致的缺血性脑卒中[1]。康复训练在脑卒中后功能恢复中发挥重要作用,绝大多数患者可以通过康复训练达到生活自理。除常规康复训练及治疗可以帮助脑卒中患者外,改善患者的社交及生活环境也可以影响功能恢复的进

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