肝动脉化疗栓塞联合CT引导热消融治疗肝内胆管癌

发布时间：2018-01-10 02:33

本文关键词：肝动脉化疗栓塞联合CT引导热消融治疗肝内胆管癌　出处：《介入放射学杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨TACE联合CT引导热消融(射频/微波)治疗肝内胆管癌(ICC)的疗效及安全性。方法回顾分析2009年9月至2013年7月用TACE序贯CT引导下RFA/MWA治疗病理诊断的ICC患者14例,18个病灶,病灶最大径(多个病灶取最大径之和)2.2~7.2 cm,平均(4.2±1.4)cm。TACE随访病灶的完全消融率、手术并发症、无瘤生存时间及总生存时间。结果 15个病灶实现了完全消融,肿瘤的完全消融率为83.3%(15/18),中度并发症的发生率为6.2%,无严重并发症及死亡患者。术后随访6~44个月,平均(16.0±10.3)个月。至随访结束,死亡6例(42.9%,6/14)。完全消融患者的中位无瘤生存时间为17个月,全组患者的中位生存时间为20个月,1、2、3年总体生存率分别为82.5%、41.3%及20.6%。结论TACE联合CT引导热消融可作为ICC治疗的选择之一。
[Abstract]:Objective to investigate the effect of TACE combined with CT guided thermal ablation (RF / microwave) in the treatment of intrahepatic cholangiocarcinoma. Methods from September 2009 to July 2013, 14 patients with ICC were treated with RFA/MWA guided by TACE sequential CT. The complete ablation rate and operative complications of 18 lesions with the maximum diameter (the sum of the maximum diameters of multiple lesions being 2.2 卤7.2 cm, mean 4.2 卤1.4 cm. TACE) were followed up. Results 15 lesions were completely ablated, the complete ablation rate was 83.3% and the incidence of moderate complications was 6.2%. There were no serious complications and death. The follow-up period was 6 ~ 44 months (mean 16.0 卤10.3) months. At the end of follow-up, 6 cases died 42.9%. The median tumor-free survival time of patients with complete ablation was 17 months, the median survival time of the patients was 20 months / 1 / 2, and the overall 3-year survival rate was 82.5%, respectively. Conclusion TACE combined with CT guided thermal ablation may be one of the options for the treatment of ICC.
【作者单位】：首都医科大学附属佑安医院肿瘤微创介入中心;
【基金】：北京市丰台区卫生计生系统科研项目(2016-63)
【分类号】：R730.44;R735.8
【正文快照】： 肝内胆管癌(ICC)是相对少见的肝内恶性肿瘤,占肝内原发恶性肿瘤的5%~30%,近年来其发病率呈上升趋势。相对于肝细胞癌(HCC),ICC恶性程度更高,预后更差,未经治疗的ICC中位生存时间只有3.9个月[1]。外科手术切除目前仍是ICC的首选治疗方法,但由于ICC患者诊断时多已属中晚期,适

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