血液透析患者免疫系统紊乱的机理研究进展

发布时间：2018-02-16 16:08

  本文关键词： 晚期肾病 血液透析 免疫系统 免疫系统刺激物 免疫紊乱　出处：《现代预防医学》2017年09期 　论文类型：期刊论文

【摘要】：透析后肾组织发生慢性炎症是血液透析后的一种常见副作用,严重时会导致进展性晚期肾病,危及患者生命。在免疫学上,血液透析引起肾组织出现慢性炎症的原因是血透患者的免疫系统发生紊乱,其危险因素包括尿毒症毒素和透析相关因子等免疫系统刺激物。在免疫系统刺激物的长期刺激作用下,免疫系统紊乱主要表现在补体紊乱、先天性免疫紊乱和获得性免疫紊乱。目前国内外在血液透析患者免疫系统紊乱方面有很多新的研究,但国内没有综述,故本文将从免疫系统刺激物、补体系统紊乱、先天性免疫系统紊乱和获得性免疫系统紊乱等方面的发病机理进行阐述,为预防和治疗血液透析所引起的肾组织慢性炎症提供理论基础。
[Abstract]:Chronic inflammation of renal tissue after dialysis is a common side effect after hemodialysis. In immunology, it can lead to advanced advanced nephropathy and endanger the life of patients. The cause of chronic inflammation in renal tissue caused by hemodialysis is the disorder of the immune system of hemodialysis patients. The risk factors include immune system irritants such as uremic toxins and dialysation-related factors. Congenital immune disorders and acquired immune disorders. At present, there are many new studies on immune system disorders in hemodialysis patients at home and abroad, but there is no review in China, so this article will focus on immune system irritants, complement system disorders, The pathogenesis of congenital immune system disorder and acquired immune system disorder is expounded to provide a theoretical basis for the prevention and treatment of chronic inflammation of renal tissue caused by hemodialysis.
【作者单位】： 广州市红十字会医院;
【分类号】：R692.5
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本文编号：1515908