维持性血液透析患者的血浆可溶性尿激酶型纤溶酶原激活物受体与冠脉钙化及心血管事件的关系

发布时间：2018-02-16 13:21

本文关键词： 血液透析可溶性尿激酶型纤溶酶原激活物受体血管钙化心血管疾病　出处：《肾脏病与透析肾移植杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的:探讨维持性血液透析(MHD)患者的血浆可溶性尿激酶型纤溶酶原激活物受体(suPAR)与冠脉钙化、心血管事件与死亡的关系。方法:在2010年至2016年期间随访99例MHD患者,用ELISA方法检测血浆suPAR,用64层螺旋CT(MDCT)测定冠状动脉钙化积分(CACS),分析suPAR与CACS的关系,及其对心血管事件发生率和全因死亡的影响。结果:2010年~2016年,91例(91.9%)存在不同程度的血管钙化,Spearman相关分析中,suPAR与冠状动脉钙化程度呈正相关(P=0.001,r=0.315),与CACS100分组比较,CACS≥100分组血浆suPAR显著提高(P=0.048)。根据血浆suPAR的四分位数进行分析,发现高suPAR组心血管事件和全因死亡率最高(P0.05)。单因素COX回归分析中,suPAR是心血管事件和全因死亡的危险因素;多因素COX回归模型显示suPAR仍然是心血管事件发生的独立危险因素。结论:在MHD患者中,suPAR与冠状动脉钙化程度呈正相关,suPAR作为心血管事件发生的独立危险因素,对MHD患者心血管事件的发生有一定的预测作用。
[Abstract]:Objective: to investigate the relationship between plasma soluble urokinase-type plasminogen activator receptor (Surokinase type plasminogen activator receptor) and coronary calcification, cardiovascular events and death in patients with maintenance hemodialysis (HD). Methods: from 2010 to 2016, 99 patients with MHD were followed up. Plasma supar was detected by ELISA and coronary artery calcification score was measured by 64-slice spiral CTT. The relationship between suPAR and CACS was analyzed. Results: from 2010 to 2016, there were 91 cases (91.9%) with different degrees of vascular calcification. Spearman correlation analysis showed that there was a positive correlation between the coronary artery calcification and the degree of coronary artery calcification. Plasma suPAR was significantly increased by 0.048 渭 m. The quartile number of plasma suPAR was analyzed. It was found that cardiovascular events and total mortality were the highest in high suPAR group (P 0.05). In univariate COX regression analysis, suPAR was the risk factor of cardiovascular events and all-cause death. Multivariate COX regression model showed that suPAR was still an independent risk factor for cardiovascular events. Conclusion: in patients with MHD, suPAR is positively correlated with coronary artery calcification as an independent risk factor for cardiovascular events. It can predict the occurrence of cardiovascular events in patients with MHD.
【作者单位】：南方医科大学;广东省人民医院(广东省医学科学院)肾内科;广东省人民医院(广东省医学科学院)放射科;
【基金】：国家临床重点专科建设项目国家自然科学基金项目(81670665) 广东省自然科学基金(2014A030313544) 广州市科技计划项目(201605110852556)
【分类号】：R692.5;R54

【相似文献】