脓毒血症的流行病学与临床治疗进展

发布时间：2018-02-21 18:49

本文关键词： 脓毒血症流行病学临床治疗　出处：《中华医院感染学杂志》2017年15期 　论文类型：期刊论文

【摘要】：脓毒血症是世界上常见的、致命的、治疗费用高昂的疾病,老龄人口中尤其常见,且不同程度地影响患有癌症和潜在免疫抑制的患者;严重脓毒血症可导致多种器官功能障碍,以致产生以严重的免疫功能和分解代谢障碍为特征的慢性危重疾病状态;目前为此,很难找到一个单一的适合所有脓毒血症的方法;由于支持性医护的改善,包括快速识别脓毒血症和交付有效的抗菌药物、治疗早期脓毒性休克的流体复苏疗法、肺保护性通气、休克解决后更谨慎地使用流体治疗、更明智地使用血液制品以及减少院内二次感染,脓毒血症的预后情况已有效改善;新型治疗途径主要针对器官功能障碍,为了减少异质性及增强新疗法治疗效果,选择脓毒血症患者并将其表型用于临床试验的临床标准和生物标准需要改善。
[Abstract]:Sepsis is a common, fatal, costly disease in the world, especially among older populations, and affects patients with cancer and potential immunosuppression to varying degrees; severe sepsis can lead to multiple organ dysfunction, Resulting in a state of chronic critical disease characterized by severe immune and catabolism disorders; currently, it is difficult to find a single method suitable for all sepsis; due to improvements in supportive care, Including rapid identification of sepsis and delivery of effective antimicrobial agents, fluid resuscitation for early septic shock, lung protective ventilation, and more careful use of fluid therapy after shock resolution. Better use of blood products and reduction of secondary nosocomial infections have effectively improved the prognosis of sepsis. New treatment approaches are aimed at organ dysfunction, in order to reduce heterogeneity and enhance the efficacy of new therapies. Clinical and biological criteria for selecting sepsis patients and applying their phenotypes to clinical trials need to be improved.
【作者单位】：湖南医药学院基础医学院;华中科技大学同济医学院;湖南医药学院第一附属医院;
【分类号】：R459.7

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