单光子发射计算机断层成像在诊断口腔癌颌骨侵犯中的价值:系统评价及Meta分析

发布时间：2018-03-07 19:37

本文选题：单光子发射计算机断层成像　切入点：口腔癌　出处：《华西口腔医学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的评价单光子发射计算机断层成像(SPECT)技术在诊断口腔癌下颌骨侵犯的诊断效能。方法对5个常用数据库进行电子检索,检索时间截至2016年8月5日;并对纳入研究参考文献进行手检。研究质量由两位评价者独立使用Cochrane协作网推荐的标准进行评价并提取数据。运用STATA 11.0软件进行Meta分析。结果共纳入10篇研究,共涉及患者460名。1项研究存在低偏倚风险,2项研究存在高偏倚风险,7项研究偏倚风险不清。合并敏感度为0.99[95%可信区间=0.87~1.00]。Meta分析结果显示,合并受试者工作特征曲线(SROC)的曲线下面积(AUC)为0.93[95%可信区间=0.90~0.95],Q*点处敏感度为0.99,特异度为0.61。其合并阳性预测值为2.555,合并阴性预测值为0.015,而合并诊断比值比为5.115。结论 SPECT在诊断口腔癌下颌骨侵犯中敏感度较高,适合用于排除没有骨侵犯存在的患者,但特异度低,不适合进行确诊,临床医生应该根据具体患者情况进行合理选择。
[Abstract]:Objective to evaluate the diagnostic efficacy of single photon emission computed tomography (SPECT) in the diagnosis of mandibular invasion of oral cancer. The quality of the study was evaluated by two evaluators independently using the standard recommended by the Cochrane Cooperative Network and the data were extracted. The Meta analysis was carried out by using STATA 11.0 software. The results were included in 10 studies. A total of 460 patients were involved in 1 study with low bias risk and 2 with high bias risk. The combined sensitivity was 0.99 [95% confidence interval 0.871.00] .Meta-analysis showed that. The area under the curve combined with the operating characteristic curve of subjects was 0.93 [95% confidence interval 0.90 / 0.95] sensitivity was 0.99, specificity was 0.61.The combined positive predictive value was 2.555, the combined negative predictive value was 0.015, and the combined diagnostic ratio was 5.115.Conclusion: the combined positive predictive value is 2.555, the combined negative predictive value is 0.015, and the combined diagnostic ratio is 5.115.Conclusion the combined positive predictive value is 2.555, the combined negative predictive value is 0.015 and the combined diagnostic ratio is 5.115. SPECT is highly sensitive in the diagnosis of mandibular invasion of oral cancer. It is suitable for excluding the patients without bone invasion, but the specificity is low and not suitable for diagnosis. The clinician should make reasonable choice according to the patient's condition.
【作者单位】：清水县人民医院口腔科;口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院头颈肿瘤外科;口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院麻醉科;
【基金】：2016年四川大学优秀青年学者基金(2082604194311)~~
【分类号】：R730.44;R739.8

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