纤维束示踪成像评价复发缓解型多发性硬化患者边缘系统纤维通路损伤

发布时间：2018-04-09 18:03

本文选题：扩散磁共振成像　切入点：纤维示踪成像　出处：《中国医学影像技术》2017年08期

【摘要】：目的利用扩散张量纤维束示踪成像评估多发性硬化(MS)边缘系统纤维通路损害。方法对20例复发缓解型MS患者(MS组)和20名健康志愿者(对照组)进行纤维束示踪成像。追踪扣带束、穹窿、钩束,获得相应纤维条数、FA值、MD值。并进行统计学分析。结果与对照组比较,MS组扣带束、穹窿、钩束FA值均减低(P均0.01),MD值均升高(P均0.05)。MS组穹窿纤维条数较对照组减少(P0.001)。MS组中左侧与右侧钩束纤维条数、对照组中左侧与右侧钩束FA值、纤维条数差异均有统计学意义(P均0.05)。MS组扣带束、钩束FA值与EDSS评分呈负相关(r=-0.572、-0.665,P均0.05),MD值与EDSS评分呈正相关(r=0.627、0.603,P均0.05)。结论纤维束示踪成像对评估MS边缘系统纤维通路损害及监测临床进程有重要应用价值。
[Abstract]:Objective to evaluate the damage of fibrous pathway in multiple sclerosis (MS) limbic system by using diffuse Zhang Liang tracer imaging.Methods Fibrotracer imaging was performed in 20 patients with relapsed MS and 20 healthy volunteers (control group).The FA value and MD value of the corresponding fiber strips were obtained by tracing the buckling straps, fornix and hook bundles.Statistical analysis was carried out.There were significant differences in the number of fiber strips. The FA value of hook bundle was negatively correlated with EDSS score (P < 0.05) and EDSS score (P < 0.05). There was a positive correlation between FA value of hook bundle and EDSS score (P < 0.05) and EDSS score (r = 0.627) and 0.603% (P < 0.05).Conclusion tracer imaging has important value in assessing the damage of the fibrous pathway in MS limbic system and monitoring the clinical process.
【作者单位】：重庆医科大学附属第一医院放射科;
【基金】：国家自然科学基金面上项目(81371523) 重庆市卫生计生委医学科研计划项目(2016ZDXM002、2012-1-017) 国家临床重点专科建设项目(2013-544)
【分类号】：R445.2;R744.51

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