超声造影及血流检测评价猪脑死亡供肝质量的研究

发布时间：2018-05-03 11:35

本文选题：超声造影 + 脑死亡　；参考：《中国超声医学杂志》2017年01期

【摘要】：目的应用超声造影及血流检测评价猪脑死亡(BD)后不同时间肝损伤的程度。方法 8只长白猪,制备BD模型前作为对照组,BD后按照不同时间点分确认BD组3、6、9h组。各组分别行肝脏超声造影及血流检测,定量分析并与病理对照。结果 (1)超声造影:肝动脉到达时间(ATHA)、门静脉到达时间(ATPV)及下腔静脉到达时间(ATIVC)随BD时间延长均呈增加趋势(P0.01、0.05、0.01)。(2)血流检测:(1)肝动脉收缩期峰值流速(PSV)3h组较对照组升高,随后减低(P0.05);肝动脉阻力指数(RI)在BD后呈现明显升高趋势(P0.05)。(2)门静脉平均流速(MVPV)随BD时间延长呈下降趋势(P0.05)。(3)病理学:各组、ATPV与病理学变化均呈正相关性(P0.01、0.01)。结论应用超声造影及血流检测可动态观察肝脏灌注并测量血流参数,能有效评价脑死亡供肝损伤程度。
[Abstract]:Objective to evaluate the degree of liver injury at different time after brain death (BDD) in pigs by contrast-enhanced ultrasonography and blood flow measurement. Methods eight Landrace pigs were used as control group before the preparation of BD model. The BD group was divided into 3 groups and 6 h group according to different time points. Each group were examined by contrast-enhanced hepatic ultrasound and blood flow, quantitative analysis and pathological control. Results 1) contrast-enhanced echocardiography: the time of arrival of hepatic artery and the arrival time of portal vein and inferior vena cava were increased with the prolongation of BD time (P 0.01 0. 05 0. 01 n. 2) blood flow measurement: 1) the peak systolic velocity of hepatic artery and the peak flow rate of PSV3 h group were higher than those of the control group. After BD, the mean flow velocity of portal vein (MVPV2) decreased with the prolongation of BD (P0.05. 0. 0. 3) Pathology: there was a positive correlation between ATPV and pathological changes in each group (P 0. 01 0. 01). Conclusion Ultrasound and blood flow detection can dynamically observe liver perfusion and measure blood flow parameters, and can effectively evaluate the degree of brain death donor liver injury.
【作者单位】：天津市第一中心医院超声科;
【基金】：天津市卫生行业重点攻关项目(No.13KG102) 天津市应用基础与前沿技术研究计划项目(No.15JCYBJC27000) 天津市卫生局科技基金项目(No.2014KZ023)
【分类号】：R445.1;R657.3

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