胃癌扩散加权成像ADC值与EGFR、Ki-67表达的相关性

发布时间：2018-05-17 17:22

本文选题：胃肿瘤 + 磁共振成像　；参考：《放射学实践》2017年09期

【摘要】：目的:初步探讨胃癌磁共振扩散加权成像(DWI)表观扩散系数(ADC)值与表皮生长因子受体(EGFR)、Ki-67表达的相关性。方法:回顾性分析68例胃癌患者的临床及MRI资料,同时采用免疫组化法检测胃癌中EGFR及Ki-67的表达,分析ADC值(包括平均ADC值和最小ADC值)与EGFR、Ki-67表达的关系。结果:平均ADC值及最小ADC值在不同EGFR表达状态中差异均有统计学意义(P0.05),其中EGFR表达中阴性组的平均ADC值和最小ADC值均高于EGFR阳性组[(1.106±0.196)×10~(-3) mm~2/s和(0.918±0.164)×10~(-3) mm~2/s,P0.001;(0.989±0.198)×10~(-3) mm~2/s和(0.835±0.170)×10~(-3) mm~2/s,P=0.002]。EGFR表达与平均ADC值、最小ADC值间均存在显著相关性(r=-0.432,P0.001;r=-0.382,P=0.001),而Ki-67表达与ADC值间无明显相关性(P0.05)。结论:胃癌ADC值与肿瘤细胞EGFR表达间存在相关性,ADC值有望作为临床治疗胃癌时辅助评估EGFR表达的指标。
[Abstract]:Objective: To investigate the correlation between the apparent diffusion coefficient (ADC) value of DWI and the expression of epidermal growth factor receptor (EGFR) and Ki-67. Methods: the clinical and MRI data of 68 patients with gastric cancer were analyzed retrospectively, and the expression of EGFR and Ki-67 in gastric cancer was detected by immunohistochemical method, and the value of ADC (including the average ADC value) was analyzed. The relationship between the minimum ADC value and the expression of EGFR and Ki-67. Results: the mean ADC and minimum ADC values were statistically significant in different EGFR expressions (P0.05), and the average ADC and the minimum ADC values of the negative groups in EGFR expression were higher than those of the EGFR positive group [(1.106 + 0.196) * 10~ (0.918 + 0.164) and (0.98) 9 + 0.198) x 10~ (-3) mm~2/s and (0.835 + 0.170) x 10~ (-3) mm~2/s, P=0.002].EGFR expression and the average ADC value, there is a significant correlation between the minimum ADC value (r=-0.432, P0.001, r=-0.382,). Conclusion: there is a correlation between the value of the expression and the expression of the tumor. It is helpful to evaluate the expression of EGFR in the treatment of gastric cancer.
【作者单位】：南京大学医学院附属鼓楼医院医学影像科;南京医科大学鼓楼临床医学院;南京大学医学院附属鼓楼医院病理科;南京大学医学院附属鼓楼医院普通外科;
【基金】：国家自然科学基金资助项目(81371516)
【分类号】：R445.2;R735.2

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