射血分数保留的老年慢性心力衰竭患者的N末端脑钠肽前体水平及超声特点

发布时间：2018-05-21 03:45

本文选题：射血分数保留的心力衰竭 + N末端脑钠肽前体　；参考：《中国循证心血管医学杂志》2017年03期

【摘要】：目的分析射血分数保留的老年慢性心力衰竭患者的N末端脑钠肽前体(NT-pro BNP)水平及超声特点。方法连续入选2013年3月~2016年5月于廊坊市第四人民医院心内科住院治疗的老年慢性心力衰竭(CHF)患者186例,分为射血分数保留的心力衰竭(HFp EF)组和射血分数降低的心力衰竭组(HFrEF组)。两组受试者均进行一般资料采集、实验室检测及超声检查。结果 1HFp EF组血浆NT-pro BNP水平低于HFrEF组(P0.05)、总胆固醇水平高于HFrEF组(P0.05)。2HFp EF组左室舒张末内径(LVEDD)、左房内径(LAD)、左室舒张末容积(LVEDV)、二尖瓣舒张早期最大血流速度/舒张晚期最大血流速度(E/A)小于HFrEF组(P均0.05),室间隔厚度(VST)、左室后壁厚度(LVPWT)、左室射血分数(LVEF)大于HFrEF组(P均0.05)。3HFp EF组血浆NT-pro BNP水平与HYHA分级、LVEDD、LAD呈正相关,相关系数分别为0.216、0.307、0.253(P均0.05);与LVEF呈负相关,相关系数为-0.197(P0.05)。结论 NT-pro BNP及超声指标与HFp EF严重程度密切相关,二者联合应用能够为HFp EF的诊断及病情评估提供重要依据。
[Abstract]:Objective to analyze the N terminal brain natriuretic peptide precursor (NT-pro BNPP) and its ultrasonic features in elderly patients with chronic heart failure (CHF) with retained ejection fraction (EF). Methods 186 elderly patients with chronic heart failure (CHF) who were hospitalized in Department of Cardiology, fourth people's Hospital of Langfang City from March 2013 to May 2016 were enrolled in this study. The patients were divided into two groups: HFP EFB group and HFrEF group. General data collection, laboratory examination and ultrasonic examination were performed in both groups. Results the level of plasma NT-pro BNP in 1HFp EF group was lower than that in HFrEF group, and the total cholesterol level was higher than that in HFrEF group. The left ventricular end-diastolic diameter (LVEDDD), left atrial diameter (Ladd), left ventricular end-diastolic volume (LVEF), peak early diastolic velocity of mitral valve / late diastolic peak in HFrEF group were higher than those in HFrEF group. Large blood flow velocity (E / A) was lower than that in HFrEF group (P < 0.05), ventricular septal thickness (VST), left ventricular posterior wall thickness (LVEF) and left ventricular ejection fraction (LVVEF) were significantly higher than those in HFrEF group (P < 0.05). Plasma NT-pro BNP level in 0.05).3HFp EF group was positively correlated with HYHA grade (LVEDDLAD). The correlation coefficient was 0.2160.3070.253 (P < 0.05), and negatively correlated with LVEF (-0.197) (P 0.05). Conclusion NT-pro BNP and ultrasound are closely related to the severity of HFp EF, and their combined use can provide an important basis for the diagnosis and evaluation of HFp EF.
【作者单位】：廊坊市第四人民医院超声科;廊坊市第四人民医院心内科;廊坊市第四人民医院眼科;廊坊市第四人民医院神经内科;
【分类号】：R541.6;R445.1

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