2014-2016年医院ICU肺炎克雷伯菌分布及耐药性分析

发布时间：2018-05-21 04:35

本文选题：肺炎克雷伯菌 + 重症医学科　；参考：《中华医院感染学杂志》2017年20期

【摘要】：目的探讨重症医学科(ICU)患者肺炎克雷伯菌(KPN)感染的分布及耐药趋势,为临床感染控制及用药提供依据。方法选取2014年1月-2016年12月医院ICU分离出的551株KPN,并进行病原菌鉴定及药敏试验。结果 2014-2016年ICU KPN检出率分别为16.29%、14.56%、15.25%,合计3年检出率15.35%;主要标本来源于痰液和血液;肺炎克雷伯菌对氨苄西林、头孢曲松、氨苄西林舒巴坦、氨曲南、头孢他啶耐药率较高,分别是99.82%、57.71%、56.81%、49.36%、42.65%,但呈下降趋势,对亚胺培南耐药率分别是39.88%、33.55%、17.32%,呈明显下降。结论连续3年ICU感染KPN检出率无上升,耐药率呈逐年下降趋势;建议加强多药耐药菌监测、抗菌药物使用管理,针对药敏结果选用敏感性强的抗菌药物对降低KPN扩散有重要作用。
[Abstract]:Objective to investigate the distribution and drug resistance trend of Klebsiella pneumoniae (KPN) infection in ICU patients and to provide the basis for clinical infection control and drug use. Methods 551 strains of KPN isolated from ICU in December -2016 in January 2014 were selected and the pathogen identification and drug sensitivity test were carried out. The results of ICU KPN detection were 16.29%, 14.56% respectively. 15.25%, the total detection rate of 3 years was 15.35%, the main specimens were from sputum and blood, and Klebsiella pneumoniae had a high resistance rate to ampicillin, ceftriaxone, ampicillin sulbactam, amamennan, and ceftazidime, which were 99.82%, 57.71%, 56.81%, 49.36%, 42.65% respectively, but the resistance rate was 39.88%, 33.55%, 17.32%, respectively. Conclusion the detection rate of ICU infection of KPN did not rise for 3 years, and the resistance rate was declining year by year. It is suggested to strengthen the monitoring of multidrug resistant bacteria, use management of antibiotics and select sensitive antibiotics to reduce the diffusion of KPN.
【作者单位】：东南大学附属中大医院感染管理科;东南大学附属中大医院检验科;东南大学附属中大医院药剂科;东南大学附属中大医院重症医学科;
【基金】：南京市药学会资助项目(2016YX009)
【分类号】：R446.5

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