2006—2015年肺炎克雷伯菌耐药性监测

发布时间：2018-06-25 11:48

本文选题：肺炎克雷伯菌 + 抗菌药物　；参考：《中华医院感染学杂志》2017年18期

【摘要】：目的了解医院2006-2015年临床分离的肺炎克雷伯菌分布和耐药性变迁,为临床合理使用抗菌药物提供参考。方法回顾性分析2006-2015年医院门诊、急诊和住院患者中分离的肺炎克雷伯菌,对其细菌分布及药物敏感性进行分析。结果 2006-2015年共分离出肺炎克雷伯菌7442株,96.86%菌株分离自住院患者,52.14%菌株分离自痰标本;肺炎克雷伯菌对抗菌药物的耐药性呈整体上升趋势;产超广谱β-内酰胺酶(ESBLs)肺炎克雷伯菌的检出率约60.00%;肺炎克雷伯菌对头孢哌酮/舒巴坦、头孢他啶和氨曲南的耐药率分别由2.20%、20.10%、17.30%上升至27.40%、41.60%、48.60%,上升明显;ICU科分离的肺炎克雷伯菌耐药率最高,其次为儿科、外科和内科。结论医院分离的肺炎克雷伯菌耐药情况非常严峻,分离自不同年龄段和科室的菌株对抗菌药物的耐药性相差较大,必须加强抗菌药物管理,继续开展病原菌分布及其耐药性监测,用于指导临床医师合理使用抗菌药物,控制耐药菌株在医院中的流行。
[Abstract]:Objective to investigate the distribution and drug resistance of Klebsiella pneumoniae isolated in hospital from 2006 to 2015, and to provide reference for rational use of antimicrobial agents. Methods Klebsiella pneumoniae isolated from outpatient, emergency and inpatients in hospital from 2006 to 2015 were analyzed retrospectively. The distribution and drug sensitivity of Klebsiella pneumoniae were analyzed. Results A total of 7442 strains of Klebsiella pneumoniae were isolated from hospital patients from 2006 to 2015. 52.14% strains of Klebsiella pneumoniae were isolated from sputum samples, and the resistance of Klebsiella pneumoniae to antimicrobial agents showed an overall upward trend. The detection rate of extended-spectrum 尾 -lactamases (ESBLs) producing Klebsiella pneumoniae was about 60.00. the effect of Klebsiella pneumoniae on cefoperazone / sulbactam, The drug resistance rates of ceftazidime and aztreonam increased from 2.20% to 27.40% from 20.10% to 27.40% and 41.60% to 48.60%, respectively. The resistance rate of Klebsiella pneumoniae isolated from ICU was the highest, followed by paediatrics, surgery and internal medicine. Conclusion the drug resistance of Klebsiella pneumoniae isolated from hospitals is very serious. The antibiotic resistance of strains isolated from different age groups and departments is quite different, so it is necessary to strengthen the management of antimicrobial agents. To continue to monitor the distribution of pathogens and drug resistance, to guide clinicians to use antibiotics rationally and to control the prevalence of drug-resistant strains in hospitals.
【作者单位】：广西医科大学第一附属医院医院感染管理科;广西医科大学第一附属医院检验科;
【分类号】：R446.5

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