常见输血不良反应发生率及相关危险因素探讨

发布时间：2018-06-28 18:36

  本文选题：输血不良反应 + 相关因素　； 参考：《中国输血杂志》2017年10期

【摘要】：目的分析临床输血不良反应的发生特点,寻找相关危险因素,探讨降低输血不良反应的预防措施。方法回顾性分析复旦大学附属妇产科医院及上海中医药大学附属上海市中西医结合医院2014年1月-2017年1月内接受输血治疗的1 058例病例资料,其中包括120例发生输血不良反应患者;分析常见输血不良反应发生率及原因,运用单因素及多因素Logistic回归分析输血不良反应发生相关的危险因素。结果常见输血不良反应发生率约11.3%(过敏反应约5.1%,发热反应约6.2%);血浆与冷沉淀引起的输血不良反应达到70%以上,去白细胞悬浮红细胞最少;过敏反应、发热反应所占的病例分别为45%(54/120)、55%(66/120);观察组与对照组在输血次数、发血至开始输血时间间隔、输血类型均存在差异(χ2=40.110,P0.001;χ2=137.924,P0.001;χ2=289.318,P0.001);多因素Logistic回归分析显示输血次数、输血类型、发血至开始输血间隔为输血不良反应独立预测因子(P0.05)。结论输血不良反应的主要危险因素为输血次数、输血类型、血库发血到开始输血的时间间隔,因此临床输血应严格掌握适应证,合理选择血液制品,降低输血不良反应的发生。
[Abstract]:Objective to analyze the characteristics of adverse reactions of blood transfusion, to find out the related risk factors and to explore the preventive measures to reduce the adverse reactions of blood transfusion. Methods the data of 1 058 cases who received blood transfusion treatment from January 2014 to January 2017 were retrospectively analyzed in Fudan University Obstetrics and Gynecology Hospital and Shanghai University of traditional Chinese Medicine affiliated Shanghai Integrated Chinese and Western Medicine Hospital from January 2014 to January 2017. The incidence and causes of common adverse reactions of blood transfusion were analyzed and the risk factors related to adverse reactions of blood transfusion were analyzed by univariate and multivariate logistic regression analysis. Results the incidence rate of common transfusion adverse reactions was about 11.3% (allergic reaction about 5.1%, fever reaction about 6.2%), the adverse reaction of blood transfusion caused by plasma and cryoprecipitation was more than 70%, leucocytic leucopenia erythrocyte was the least, allergic reaction was the lowest. Febrile reaction accounted for 45% (54 / 120) and 55% (66 / 120), respectively. There were significant differences between the observation group and the control group in the number of blood transfusions, the interval between the blood transfusion and the beginning of blood transfusion (蠂 2 / 40.110 / P 0.001; 蠂 ~ 2137.924 / P 0.001; 蠂 ~ 2 / 289.318P0.001); multivariate logistic regression analysis showed that the number of blood transfusions, the types of blood transfusions, and the types of blood transfusions were significantly different between the two groups. The interval from the onset of blood transfusion to the beginning of blood transfusion was an independent predictor of adverse reactions of blood transfusion (P0.05). Conclusion the main risk factors of adverse reaction of blood transfusion are the times of transfusion, the type of blood transfusion, the interval between blood transfusion and blood transfusion. Therefore, the indication of clinical transfusion should be strictly grasped, the blood products should be selected reasonably, and the occurrence of adverse reaction of blood transfusion should be reduced.
【作者单位】： 上海复旦大学附属妇产科医院;上海中医药大学附属上海市中西医结合医院;
【分类号】：R457.13
，

本文编号：2078959