阿尔茨海默病发病进程中垂体大小变化的MRI初步研究

发布时间：2018-10-08 20:38

【摘要】：目的:采用磁共振成像(magnetic resonance imaging,MRI)对阿尔茨海默病(Alzheimer’s disease,AD)发病进程中垂体大小有无变化进行初步研究。方法:采集正常对照(normal control,NC)组41例、轻度认知损害(mild cognitive impairment,MCI)组36例、AD组41例共118例受试者颅脑MRI图像,测量每例垂体前后径、宽径、高径、体积、垂体柄长径并进行标化,采用统计学方法进行组间比较。结果:垂体标化前后径MCI组大于NC组(t=3.882,P=0.000)及AD组(t=5.533,P=0.000)。垂体标化体积MCI组大于NC组(t=2.192,P=0.030)及AD组(t=2.223,P=0.028)。垂体标化宽径、标化高径及标化垂体柄长径MCI组与NC组,MCI组与AD组组间无统计学差异(P0.05)。结论:MCI患者垂体大于正常人及AD患者,推测在AD发病进程中的MCI期可能存在垂体增大。
[Abstract]:Objective: to study the changes of pituitary size in Alzheimer's disease (Alzheimer's disease,AD) by magnetic resonance imaging (magnetic resonance imaging,MRI). Methods: the craniocerebral MRI images of 118 subjects were collected from 41 cases of normal control group (normal control,NC) and 36 cases of mild cognitive impairment (mild cognitive impairment,MCI) group (AD group, 41 cases). The anterior and posterior diameter, width diameter, height diameter, volume and length of pituitary stalk of each case were measured and standardized. Statistical methods were used to compare the two groups. Results: the anterior and posterior diameter of pituitary gland in MCI group was larger than that in NC group (t = 3.882) and AD group (t = 5.533P = 0.000). The standard volume of pituitary gland in MCI group was larger than that in NC group (t 2. 192 P 0. 030) and AD group (t 2. 223 P 0. 028). There was no significant difference between MCI group and NC group and AD group (P0.05). Conclusion the pituitary gland in the patients with AD is larger than that in the normal and AD patients. It is speculated that there may be an increase in the pituitary gland in the MCI stage of the pathogenesis of AD.
【作者单位】：重庆医科大学附属第一医院放射科;重庆医科大学基础医学院解剖学教研室法医学与生物医学信息研究室;第三军医大学西南医院放射科;
【基金】：国家临床重点专科资助项目(编号:国卫办医函[2013]544号)
【分类号】：R445.2;R749.16

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