正常下肢动脉缺血模型肌肉微循环MR多序列成像研究

发布时间：2018-10-09 10:05

【摘要】：目的探索血氧水平依赖(BOLD)、体素内不相干运动(IVIM)、动脉自旋标记(ASL)磁共振技术研究小腿肌肉缺血灌注的可行性。方法对15名健康志愿者的一侧大腿根部给予不同程度压力,分别在加压前(P_0),收缩压基础上20 mmHg(P_(20))、收缩压基础上40 mmHg(P_(40))和释放压力后(Precovery)在3.0 T磁共振扫描仪上进行双小腿BOLD、IVIM和ASL成像。通过相应后处理软件对加压腿和对侧未加压小腿胫骨前肌、腓骨长肌、比目鱼肌、腓肠肌的BOLD-T_2~*值、IVIM-f值和ASL-BF值进行测量。通过经皮氧分压仪在成像区域测得4种状态下的经皮氧分压(TcPO_2)值作为对比参考。结果 4种不同状态下,加压侧小腿肌肉BF值、f值和T_2~*值都具有统计学意义(P0.05),但胫骨前肌f值没有统计学意义。在P_(20)和P_(40)这两种状态下,加压侧小腿肌肉BF值和T_2~*值均明显低于加压前(P0.008)而f值均高于加压前。在P_(40)状态下,加压侧和对照侧相比,除胫骨前肌T_2~*值无统计学意义外,其余肌肉BF值、f值和T_2~*值具有显著性差异。在P_(20)状态下加压侧和对照侧相比,两组腓肠肌的BF值和T_2~*值存在显著性差异。释放压力后所有的值趋向基线值。BF值和T_2~*值与TcPO_2呈正相关(分别ρ=0.465,P=0.001、ρ=0.522,P0.001〗)。f值与TcPO_2呈负相关(ρ=-0.351,P=0.018)。结论 ASL-BF、BOLDT_2~*、IVIM-f值的变化可以评估小腿肌肉血流灌注情况,BF值和T_2~*值与TcPO_2值具有正相关性而f值与TcPO_2值具有负相关性。
[Abstract]:Objective to explore the feasibility of using spin-labeled (IVIM), artery spin-labeled (ASL) magnetic resonance technique to study the myocardial ischemia and perfusion of calf muscles in (BOLD), voxel dependent blood oxygen level. Methods 15 healthy volunteers were subjected to different degrees of pressure on the root of one thigh. BOLD,IVIM and ASL were performed on the 30-T MRI scanner before compression, 20 mmHg on the basis of systolic pressure (40 mmHg (P40) on the basis of P20), systolic blood pressure and 40 mmHg (P40) on the basis of P20), systolic blood pressure, respectively) on 3.0T MRI scanner. The BOLD-T_2~* values of tibial anterior muscle, fibula longus muscle, soleus muscle and gastrocnemius muscle were measured by corresponding post-processing software. The transdermal oxygen partial pressure (TcPO_2) values in four states were measured by the transdermal oxygen partial pressure meter in the imaging region as a reference. Results in the four different states, the BF value and the T _ 2 value of the leg muscles in the compression side were statistically significant (P0.05), but the f value of the tibial anterior muscle was not statistically significant. Under the condition of P20 and P40, the values of BF and T _ 2T _ 2 * of the leg muscles in the compression side were significantly lower than those before compression (P 0.008), and the f values were higher than those before compression. Under P40 condition, there was significant difference in BF value between the compression side and the control side, except for the tibial anterior muscle T _ 2T _ 2 *, and there was a significant difference between the BF value and T _ 2T _ 2 value of the other muscles. There was a significant difference in BF value and T _ 2T value of gastrocnemius muscle between the pressurized side and the control side in P20 state. All values after release of pressure tended to baseline value. BF value and T _ 2C _ (2) * value were positively correlated with TcPO_2 (蟻 ~ (0.465U) P ~ (0.001), 蟻 ~ (0. 522) P ~ (0.001). F values were negatively correlated with TcPO_2 (蟻 ~ (-0.351g) P ~ (0.018). Conclusion the changes of ASL-BF,BOLDT_2~*,IVIM-f value can be used to evaluate the blood perfusion of calf muscle. There is a positive correlation between BF value and TcPO_2 value, but a negative correlation between f value and TcPO_2 value.
【作者单位】：上海交通大学医学院附属仁济医院放射科;
【基金】：上海市重点学科建设项目资助(编号:S30203) 上海高校示范性全英语课程建设基金资助项目(沪教委高[2015]15号)
【分类号】：R445.2;R543.5

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