冠心病患者颈动脉粥样硬化的超声特征及其与病情严重程度的相关性

发布时间：2018-10-12 15:18

【摘要】：目的:探讨冠心病患者颈动脉粥样硬化的超声特征及其与病情严重程度的相关性。方法:收集在本院接受治疗的冠心病患者180例作为观察组,根据冠状动脉狭窄程度分为单支病变组50例、双支病变组72例、三支病变组58例;另取同期在本院进行体检的健康人50例作为对照组。采用颈动脉超声检测颈动脉粥样硬化参数,采用心脏彩色多普勒超声检测心功能参数,采用酶联免疫吸附法(ELISA)检测血清内皮功能指标,采用Pearson检验分析颈动脉超声参数与心功能、内皮功能的相关关系。结果:观察组颈动脉超声参数β、Ep、AC、PWVβ值高于对照组,随着冠脉病变程度增加,β、Ep、AC、PWVβ值改变程度加剧(P0.05);观察组心功能参数LVEDD、LVESD值高于对照组,LVEF值低于对照组,随着冠脉病变程度增加,LVEDD、LVESD、LVEF值改变程度加剧(P0.05);观察组的内皮功能指标ET-1、vWF水平高于对照组,NO水平低于对照组,随着冠脉病变程度增加,ET-1、vWF、NO水平改变程度加剧(P0.05)。冠心病患者颈动脉超声参数β、Ep、AC、PWVβ值与心功能参数、内皮功能指标水平均呈直接相关关系。结论:冠心病患者颈动脉粥样硬化的超声参数水平与病变严重程度直接相关,可作为早期病情判断的无创、可靠手段。
[Abstract]:Objective: to investigate the ultrasonic features of carotid atherosclerosis and its correlation with severity of coronary heart disease. Methods: 180 cases of coronary heart disease treated in our hospital were divided into three groups according to the degree of coronary artery stenosis: 50 cases in single vessel group, 72 cases in double vessel group and 58 cases in three vessel group. Another 50 healthy people who were examined in our hospital at the same time were taken as control group. Carotid artery ultrasound was used to detect carotid atherosclerosis parameters, heart color Doppler ultrasound was used to detect cardiac function parameters, and enzyme linked immunosorbent assay (ELISA) was used to detect serum endothelial function. The relationship between carotid ultrasound parameters and cardiac function and endothelial function was analyzed by Pearson test. Results: the parameters of carotid artery ultrasound 尾 and Ep,AC,PWV 尾 in the observation group were higher than those in the control group, and the changes of 尾 and Ep,AC,PWV 尾 were aggravated with the increase of coronary artery lesion (P0.05), the LVEDD,LVESD value of cardiac function parameter in the observation group was higher than that in the control group, and the LVEF value was lower than that in the control group. With the increase of coronary lesions, the change of LVEDD,LVESD,LVEF increased (P0.05); the ET-1,vWF level of endothelial function in the observation group was higher than that of the control group, and the level of NO was lower than that of the control group. With the increase of the severity of coronary artery lesion, the ET-1,vWF,NO level was increased (P0.05). Carotid ultrasound parameters 尾 and Ep,AC,PWV 尾 were directly correlated with cardiac function and endothelial function in patients with coronary heart disease. Conclusion: the ultrasonic parameters of carotid atherosclerosis in patients with coronary heart disease are directly related to the severity of the disease and can be used as a noninvasive and reliable method for early diagnosis of the disease.
【作者单位】：郑州大学第五附属医院超声诊断科;
【基金】：陕西省教育厅基金项目(12JK0701)~~
【分类号】：R541.4;R445.1

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