表观扩散系数值离散系数在乳腺良恶性病变鉴别诊断中的应用

发布时间：2018-11-06 13:26

【摘要】：目的:探讨表观扩散系数(ADC)值的离散系数对于乳腺良恶性病变鉴别诊断的应用价值。方法:搜集96例患者磁共振乳腺病灶98个,分别测量每一病灶ADC值的均值(x)及标准差(s),并计算每一个病灶ADC值的离散系数CV(CV=s/x)。评估病灶ADC值均值及CV的诊断效能。结果:乳腺良恶性病变组ADC值均值[良性(1.42±0.32)×10~(-3)mm~2/s,恶性(1.04±0.29)×10~(-3)mm~2/s]及CV(良性0.10±0.03,恶性0.17±0.04),两组间均有统计学差异(P0.0001)。乳腺良性与恶性病变之间ADC-CV差异的效应量(Cohen's d值,1.98)高于良性与恶性病变之间ADC均值差异的效应量(1.25)。ADC-CV ROC曲线的AUC(0.935±0.0227)也显著大于ADC均值ROC曲线的AUC(0.790±0.0447)(P0.01)。结论:乳腺病变DWI检查中ADC-CV较ADC值均值在诊断乳腺良恶性病变中具有更高的诊断效能。
[Abstract]:Objective: to evaluate the value of discrete coefficient of apparent diffusion coefficient (ADC) in differential diagnosis of benign and malignant breast lesions. Methods: 98 MRI breast lesions were collected in 96 patients. The mean (x) and standard deviation (s), of ADC were measured respectively and the CV (CV=s/x) of ADC value of each lesion was calculated. To evaluate the mean value of ADC and the diagnostic efficacy of CV. Results: the mean ADC values of benign and malignant breast lesions [benign (1.42 卤0.32) 脳 10 ~ (-3) mm~2/s, and malignant (1.04 卤0.29) 脳 10 ~ (-3) mm~2/s] and CV (benign 0.10 卤0.03, malignant 0.17 卤0.04) were compared. There was statistical difference between the two groups (P 0.0001). The (Cohen's d value of ADC-CV difference between benign and malignant breast lesions, The AUC of ADC-CV ROC curve (0.935 卤0.0227) was significantly higher than that of ADC mean ROC curve (0.790 卤0.0447) (P0.01). Conclusion: ADC-CV in DWI is more effective than ADC in the diagnosis of benign and malignant breast lesions.
【作者单位】：中国医科大学肿瘤医院/辽宁省肿瘤医院医学影像科;
【基金】：国家公益性行业科研专项“分子影像学在女性常见恶性肿瘤(乳腺癌、宫颈癌)早期诊断、治疗疗效及预后评估中的应用研究”(201402020)
【分类号】：R445.2;R737.9

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