血小板反应蛋白-1与维持性血液透析患者微炎症状态的相关性

发布时间：2018-11-20 16:45

【摘要】：目的:评价血小板反应蛋白-1(TSP-1)水平与维持性血液透析(MHD)患者微炎症状态间的相关性,探讨其对MHD患者预后判断的临床价值。方法:选择长期规律透析的MHD患者,随访观察2年,定期检测患者血中TSP-1水平和临床及炎症相关指标水平。根据TSP-1水平不同,分为三组,比较组间上述检测指标的差异,采用Pearson简单相关分析法分析TSP-1水平与炎症相关指标的相关性。同时观察2年间入选患者的预后转归状态,利用Kaplan Meier生存曲线及对秩数检验测定生存率,采用Cox回归分析计算风险指数HR值及95%可信区间CI值。结果:TSP-1高水平组患者血中血脂及反应体内炎症状态相关指标均高于TSP-1低水平组(P0.05),TSP-1水平和血脂及炎症指标间呈正相关。生存曲线分析结果显示TSP-1高水平组及中等水平组患者的死亡率高于TSP-1低水平组。校正年龄、血脂、白蛋白及血白蛋白等因素后,进一步行Cox风险模型分析结果示,TSP-1高水平的患者HR明显高于TSP-1低水平组(P0.001),表明体内高水平表达的TSP-1提示预后不良。结论:血清TSP-1水平与MHD患者微炎症状态密切相关,且能作为判断MHD患者预后的敏感指标。
[Abstract]:Objective: to evaluate the correlation between platelet reactive protein-1 (TSP-1) level and microinflammation in (MHD) patients with maintenance hemodialysis (HD), and to evaluate its clinical value in judging the prognosis of MHD patients. Methods: MHD patients with long term regular dialysis were followed up for 2 years. The levels of serum TSP-1, clinical and inflammatory indexes were measured regularly. According to the different levels of TSP-1, three groups were divided into three groups. The correlation between TSP-1 level and inflammation related indexes was analyzed by Pearson simple correlation analysis. The survival rate was measured by Kaplan Meier survival curve and logarithmic number test. The HR value of risk index and 95% confidence interval CI value were calculated by Cox regression analysis. Results: the serum lipids and inflammatory status in the patients with high level of TSP-1 were significantly higher than those in the low level of TSP-1 (P0.05). There was a positive correlation between the level of TSP-1 and serum lipids and inflammatory indexes. Survival curve analysis showed that the mortality of patients with high and medium levels of TSP-1 was higher than that of low levels of TSP-1. After adjusting for age, blood lipid, albumin and albumin, the results of Cox risk model analysis showed that HR in patients with high TSP-1 level was significantly higher than that in low TSP-1 group (P0.001). High expression of TSP-1 suggests poor prognosis. Conclusion: serum TSP-1 level is closely related to microinflammation in MHD patients and can be used as a sensitive index to judge the prognosis of MHD patients.
【作者单位】：西南医科大学;
【分类号】：R692.5

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