MRI弥散张量成像预测兔急性缺血性脑卒中出血性转化的价值

发布时间：2018-11-25 09:24

【摘要】：目的探讨3.0 T MRI弥散张量成像(diffusion tensor imaging,DTI)各向异性系数(fractional anisotropy,FA)在兔急性缺血性脑卒中出血性转化(hemorrhagic transformation,HT)预测中的价值。方法新西兰大白兔43只,随机分为手术组(33只)和假手术组(10只),手术组采用自体血栓法制备急性缺血性脑卒中模型,假手术组应用生理盐水代替自体血栓;手术组于模型制备成功后4 h应用尿激酶行静脉溶栓治疗,假手术组不作处理。2组分别于造模后3 h及溶栓治疗后2、12及24 h行DTI及MRI磁敏感加权成像(susceptibility weighted imaging,SWI)检查,依据末次SWI扫描是否发现缺血区域内低信号将手术组分为HT组(8只)和无HT组(25只),比较各组不同时间点FA值差异。结果假手术组术后均无行为障碍,MRI均未见异常;手术组麻醉苏醒后出现不同程度行为障碍;HT组造模后3 h及溶栓治疗后2、12及24 h FA值(0.143±0.017、0.126±0.018、0.136±0.017、0.141±0.017)低于无HT组(0.403±0.070、0.246±0.037、0.217±0.037、0.202±0.035)和假手术组(0.429±0.066、0.428±0.069 0.431±0.066、0.433±0.070)(P0.05);无HT组溶栓后2、12及24h FA值低于假手术组(P0.05),造模后3 h FA值与假手术组差异无统计学意义(P0.05)。结论兔急性脑缺血性脑卒中后发生HT可能与FA值降低有关。
[Abstract]:Objective to evaluate the value of (diffusion tensor imaging,DTI anisotropy coefficient (fractional anisotropy,FA) in the prediction of hemorrhagic transformation (hemorrhagic transformation,HT) in acute ischemic stroke in rabbits. Methods Forty-three New Zealand white rabbits were randomly divided into two groups: operation group (33 rabbits) and sham operation group (10 rabbits). The operation group was treated with intravenous thrombolytic therapy with urokinase 4 hours after the model was made, while the sham operation group was not treated. DTI and MRI magnetic sensitivity weighted imaging (susceptibility weighted imaging,SWI) were performed in the two groups at 3 h after model making and 2 h and 24 h after thrombolytic therapy, respectively. The operation group was divided into HT group (n = 8) and no HT group (n = 25) according to whether low signal was found in ischemic area by the last SWI scan. The FA values of each group were compared at different time points. Results there were no behavioral disorders and no abnormal MRI in the sham operation group, and different degree of behavioral disorder appeared in the operation group after anaesthesia recovery. The values of FA in HT group were significantly lower than those in HT group (0.403 卤0.070 卤0.246 卤0.037 卤0.217 卤0.202 卤0.035) and sham operation group (0.143 卤0.017 卤0.126 卤0.018 卤0.136 卤0.017 卤0.141 卤0.017) 3 h after model and 2 h and 24 h after thrombolytic therapy (0.403 卤0.070 卤0.217 卤0.037 卤0.202 卤0.035). 429 卤0.066 卤0.428 卤0.069 0.431 卤0.066 卤0.433 卤0.070 (P0.05); The value of FA in no HT group was significantly lower than that in sham operation group (P0.05), and there was no significant difference in FA value between model group and sham-operation group at 3 h after thrombolysis (P0.05). Conclusion HT after acute cerebral ischemic stroke in rabbits may be related to the decrease of FA.
【作者单位】：徐州市中心医院CT室;徐州医学院附属医院影像科;
【基金】：徐州市科技计划项目(KC14SH019)
【分类号】：R743.3;R445.2

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