表观弥散系数与非小细胞肺癌预后分子生物学指标的相关性分析

发布时间：2018-11-29 10:58

【摘要】：目的探讨表观弥散系数(apparent diffusion coefficient,ADC)与非小细胞肺癌(non-small cell lung cancer,NSCLC)常见的预后分子生物学指标的相关性。方法 39例经病理证实为NSCLC的患者接受磁共振弥散加权成像(diffusion weighted imaging,DWI)检查,测量病变的ADC值。采用单因素方差分析及t检验分析不同生物学指标如血中癌胚抗原(cancer embryo antigen,CEA)、组织中Ki67、甲状腺转录因子1(thyroid transcription factor 1,TTF-1)、表皮生长因子受体(epidermal growth factor receptor,EGFR)之间ADC值的差异,采用Spearman相关系数分析ADC值与不同生物学指标的相关性。结果不同生物学指标CEA、Ki67、TTF-1、EGFR之间的ADC值差异均有统计学意义(P0.01),且ADC值与上述预后相关的生物学指标均存在负相关(CEA:r=-0.77,P0.001,Ki67:r=-0.58,P0.001,TTF-1:r=-0.47,P=0.003,EGFR:r=-0.40,P=0.012)。结论 ADC值与NSCLC常见的预后分子生物学指标CEA、Ki67、TTF-1、EGFR存在负相关关系,ADC值较低往往提示CEA与Ki67水平较高,表明TTF-1阳性及EGFR突变可能。
[Abstract]:Objective to investigate the correlation between apparent diffusion coefficient (apparent diffusion coefficient,ADC) and prognostic molecular biological parameters of non-small cell lung cancer (non-small cell lung cancer,NSCLC). Methods 39 patients with pathologically proved NSCLC were examined by diffusion-weighted magnetic resonance imaging (diffusion weighted imaging,DWI) and their ADC values were measured. Univariate ANOVA and t-test were used to analyze different biological parameters, such as carcinoembryonic antigen (cancer embryo antigen,CEA) in blood, Ki67, thyroid transcription factor 1 (TTF-1) and epidermal growth factor receptor (epidermal growth factor receptor, (epidermal growth factor receptor,) in tissues. Spearman correlation coefficient was used to analyze the correlation between ADC value and different biological indexes. Results the ADC values of CEA,Ki67,TTF-1,EGFR were significantly different among different biological indexes (P0.01), and the ADC values were negatively correlated with the above prognostic biological indexes (CEA:r=-0.77,P0.001,). Ki67:r=-0.58,P0.001,TTF-1:r=-0.47,P=0.003,EGFR:r=-0.40,P=0.012) Conclusion there is a negative correlation between ADC value and CEA,Ki67,TTF-1,EGFR, a common prognostic molecular biological index of NSCLC. The lower ADC value often indicates that the level of CEA and Ki67 is higher, indicating that TTF-1 positive and EGFR mutation may be possible.
【作者单位】：第三军医大学西南医院呼吸内科;第三军医大学西南医院放射科;第三军医大学西南医院老年科;
【分类号】：R445.2;R734.2

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