MR mDIXON-Quant技术精确测量2型糖尿病合并非酒精性脂肪肝患者的肝脏脂肪含量

发布时间：2019-03-22 13:01

【摘要】：目的:探讨MR mDixon-Quant技术在精确测量2型糖尿病合并非酒精性脂肪肝患者肝脏脂肪含量中的应用价值。方法:共纳入98例研究对象,其中糖尿病组(患有2型糖尿病)男33例,女16例,对照组(无2型糖尿病)男33例,女16例。所有研究对象均行肝脏3.0T MR mDixon-Quant检查,并测量肝脏脂肪含量(%)。以脂肪含量5%作为脂肪肝的诊断标准。比较两组非酒精性脂肪肝检出率的差异。结果:糖尿病组肝脏脂肪含量中位数为5.5%(25分位值3.8%,75分位值11.0%),对照组肝脏脂肪含量中位数为3.7%(25分位值2.5%,75分位值5.7%)。糖尿病组脂肪肝总检出率为59.2%,对照组为28.6%。在男性研究对象中,糖尿病组脂肪肝检出率为63.6%(21/33),高于对照组(30.3%,10/33),差异有统计学意义(P0.05);在女性研究对象中,糖尿病组脂肪肝检出率为50.0%(8/16),高于对照组(25.0%,4/16),但差异无统计学意义(P0.05)。结论:采用MR mDixon-Quant技术可简便、精确测量2型糖尿病合并非酒精性脂肪肝患者的肝脏脂肪含量,可为疾病的筛查、诊断和治疗效果评估提供重要参考。
[Abstract]:Objective: to evaluate the value of MR mDixon-Quant in the accurate measurement of liver fat content in patients with type 2 diabetes mellitus and non-alcoholic fatty liver. Methods: a total of 98 subjects were enrolled in the study. There were 33 males and 16 females in the diabetic group (with type 2 diabetes mellitus) and 33 males and 16 females in the control group (without type 2 diabetes mellitus). Liver 3.0T MR mDixon-Quant was performed on all subjects and liver fat content (%) was measured. Fat content of 5% was used as the diagnostic criteria for fatty liver. To compare the detection rate of nonalcoholic fatty liver between the two groups. Results: the median content of liver fat in diabetic group was 5.5% (25 percentile 3.8%, 75 min 11.0%), and in control group liver fat content was 3.7% (25 percentile 2.5%), while that in control group was 3.5% (25 / 25) and 2.5% (25 / 25), respectively. 75 percents (5.7%). The total detection rate of fatty liver was 59.2% in diabetic group and 28.6% in control group. In male subjects, the detection rate of fatty liver in diabetic group was 63.6% (21 / 33), which was higher than that in control group (30.3%, 10 / 33), the difference was statistically significant (P0.05). In female subjects, the detection rate of fatty liver in diabetic group was 50.0% (8 / 16), which was higher than that in control group (25.0%, 4 / 16), but there was no significant difference (P0.05). Conclusion: MR mDixon-Quant technique is a simple and accurate method for measuring liver fat content in patients with type 2 diabetes mellitus and non-alcoholic fatty liver. It can provide important reference for screening, diagnosis and evaluation of therapeutic effect of type 2 diabetes mellitus patients with non-alcoholic fatty liver disease.
【作者单位】：北京积水潭医院放射科;安徽医科大学第四附属医院放射科;飞利浦医疗保健事业部;北京积水潭医院内分泌科;
【基金】：北京市卫生局“215”高层次卫生技术人才培养计划(2009-2-03);北京市卫生局首都卫生发展科研专项项目(首发2014-2-1122) 北京市科学技术委员会首都临床特色应用研究(Z141107002514072)
【分类号】：R445.2;R575.5;R587.1

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