Enzyme20Triggered20Carriers20Based20on20Cyclodextrin20Anchor
发布时间：2021-05-10 07:18
近年来,在纳米尺度上构建具有高负载能力、有序介孔孔道和表面改性的中空载体是药物递送的研究热点。本论文采用阿维菌素（avermectin,AVM）和氯虫苯甲酰胺（chlorantraniliprole,CLAP）作为模式药物,分别制备了不同尺寸和释放性能的功能化中空介孔二氧化硅纳米粒子（Hollow20mesoporous20silica,HMS）,负载模式药物后,采用α-环糊精作为封堵剂封闭HMS表面的介孔,制备了能够在昆虫中肠中响应酶的刺激从而释放药物的控制释放剂型（controlled20release20formulation,CRF）。主要结果如下:以不同尺寸的聚苯乙烯胶束为模板,正硅酸四乙酯在其表面水解凝聚成二氧化硅,经600℃高温煅烧去除聚苯乙烯模板,得到三种尺寸（14020nm,40020nm和1500nm）的中空介孔二氧化硅。应用N-苯基氨基丙基三甲氧基硅烷对HMS表面进行改性,以扩散的方式将农药负载至改性的HMS中。然后,采用α-环糊精作为封堵剂与苯胺基发生作用,封闭HMS表面介孔,从而制备出控制释放剂型。通过透射电子显微镜（transmission20electro...
【文章来源】：华中农业大学湖北省 211工程院校 教育部直属院校
【文章页数】：103 页
【学位级别】：博士
【文章目录】：
Abstract
摘要
List of Abbreviations
Chapter 1. Literature review
1 Introduction
1.1 Drug-delivery
1.2 Drug-carriers
1.3 Pesticides controlled release formulation
1.4 Silica-based nano-carriers' role in drug-delivery
1.5 Porous Silica Nanoparticles role in pesticides formulation
1.6 Porous Silica Nanoparticles surface functionalization
1.7 The selected pesticides
1.8 Objective of study
Chapter 2. Synthesis of three different sizes of hollow mesoporous silica carriers for controlled release of pesticides
1 Introduction
2 Materials and Methods
2.1 Materials
2.2 Characterization
3 Methods
3.1 Synthesis of CRFs
3.2 HMS surface functionalization
3.3 Loading cargo molecules and sealing HMS pores
4 CRFs characterization
4.1 CRFs thermal and light stability assay
4.2 Release figuration from CRFs under various stresses
4.3 Statistical analysis of controlled release data
4.4 Assay of biological activities of Pesticides-CRFs
5 Results
5.1 CRF fabrication
5.2 TEM and SEM observations
5.3 Fourier transmission infrared spectroscopy
5.4 N_2 adsorption-desorption isotherms
5.5 Dynamic light scattering (DLS)
5.6 Drug loading efficiency (DLE)
5.7 Thermal and light stability of CLAP-CRFs and AVM-CRFs
5.8 CLAP-CRF and AVM-CRF controlled release kinetics
5.9 CRFs biological activity
Summary
References
Appendixes
Appendix I
Appendix II
Appendix III
Publications
Acknowledgements
本文编号：3178943
【文章来源】：华中农业大学湖北省 211工程院校 教育部直属院校
【文章页数】：103 页
【学位级别】：博士
【文章目录】：
Abstract
摘要
List of Abbreviations
Chapter 1. Literature review
1 Introduction
1.1 Drug-delivery
1.2 Drug-carriers
1.3 Pesticides controlled release formulation
1.4 Silica-based nano-carriers' role in drug-delivery
1.5 Porous Silica Nanoparticles role in pesticides formulation
1.6 Porous Silica Nanoparticles surface functionalization
1.7 The selected pesticides
1.8 Objective of study
Chapter 2. Synthesis of three different sizes of hollow mesoporous silica carriers for controlled release of pesticides
1 Introduction
2 Materials and Methods
2.1 Materials
2.2 Characterization
3 Methods
3.1 Synthesis of CRFs
3.2 HMS surface functionalization
3.3 Loading cargo molecules and sealing HMS pores
4 CRFs characterization
4.1 CRFs thermal and light stability assay
4.2 Release figuration from CRFs under various stresses
4.3 Statistical analysis of controlled release data
4.4 Assay of biological activities of Pesticides-CRFs
5 Results
5.1 CRF fabrication
5.2 TEM and SEM observations
5.3 Fourier transmission infrared spectroscopy
5.4 N_2 adsorption-desorption isotherms
5.5 Dynamic light scattering (DLS)
5.6 Drug loading efficiency (DLE)
5.7 Thermal and light stability of CLAP-CRFs and AVM-CRFs
5.8 CLAP-CRF and AVM-CRF controlled release kinetics
5.9 CRFs biological activity
Summary
References
Appendixes
Appendix I
Appendix II
Appendix III
Publications
Acknowledgements
本文编号：3178943
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