多巴胺D2、D3和D4受体基因多态性与精神分裂症关联性及法医学和人类遗传学意义

发布时间：2018-02-28 12:41

本文关键词： DNA(脱氧核糖核苷酸) PCR(聚合酶链式反应) DRD2(多巴胺受体2) DRD3(多巴胺受体3) DRD4(多巴胺受体4) 基因多态性精神分裂症　出处：《中国医科大学》2005年博士论文　论文类型：学位论文

【摘要】：前言精神分裂症(schizophrenia)是一种常见的病因未明的精神疾病,在精神病中是最具代表性和最常见的一组症状群。在精神病院住院病人中占80%～90%以上,在司法精神病学鉴定的案例中占首位。本病病因不明。遗传有一定的关系,环境因素可以成为发病诱因。中枢神经系统生化代谢的研究发现,本病患者脑内多巴胺在神经突触部位有功能亢进现象,一般认为多巴胺功能亢进可能导致精神分裂症。因此,精神分裂症与多巴胺受体的遗传多态性具有一定关系。多巴胺受体被分为DRD1、DRD2、DRD3、DRD4和DRD5五种类型,目前研究较多的是DRD2、DRD3和DRD4。目的目前国内外的研究,多局限于单一基因座多态性与精神分裂症相关性的比较,而忽视了不同基因座之间的关联性作用。本研究对DRD2、DRD3和DRD4受体基因座具有多态性的变异点进行分析,通过比较正常群体与精神分裂症患者组,分别得到单一基因座多态性与精神分裂症相关性的数据,最后综合分析三个基因座多态性组合型与精神分裂症的关系,同时探讨了DRD2、DRD3和DRD4基因多态性在法医学和人类遗传学上的应用意义。材料与方法 1 样品 1.1 群体数据:127例中国汉族血液样品来自中国医科大学法医学院法医血清学教研室。
[Abstract]:Foreword. Schizophrenia (schizophrenia) is a common mental disorder of unknown etiology, which is the most representative and most common group of symptoms in psychosis. In the forensic psychiatry identification cases, the etiology of the disease is unknown. There is a certain genetic relationship, environmental factors can be the cause of the disease. Central nervous system biochemical metabolism research found, There is hyperfunction of dopamine in the brain of patients with this disease. It is generally believed that hyperactivity of dopamine may lead to schizophrenia. Schizophrenia is associated with the genetic polymorphism of dopamine receptors, which are classified into DRD1DRD2DRD2DRD3DRD4 and DRD5. Purpose. At present, most studies at home and abroad are limited to the comparison of single locus polymorphism and schizophrenia. In this study, we analyzed the polymorphism of DRD2DRD3 and DRD4 receptor loci and compared the normal population with the schizophrenic group. The data of the association between single locus polymorphism and schizophrenia were obtained. Finally, the relationship between the three locus polymorphism combinations and schizophrenia was analyzed. The significance of DRD2 DRD3 and DRD4 gene polymorphisms in forensic medicine and human genetics was also discussed. Materials and methods. 1 sample. 1.1 Group data: 127 Chinese Han blood samples were collected from the Forensic Serology Department of the Forensic Medicine College of China Medical University.
【学位授予单位】：中国医科大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：D919;R749.3

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