中国人群亲权鉴定常用STR基因座平均突变率的估计
发布时间：2019-07-20 13:41
【摘要】：目的对亲权鉴定中常用STR基因座在中国人群中的平均突变率进行估计,并与美国人群中的相应数据进行比较。方法突变数据来自按拟定标准筛选获得的15篇国内文献及本中心数据。对中国不同地区同一STR基因座突变率无显著差异的突变数据进行合并,计算中国人群该STR基因座的平均突变率,并采用Poisson分布的近似正态分布法计算该STR基因座平均突变率的95%可信区间。对中国人群和美国人群中常用STR基因座平均突变率的95%可信区间进行比较。结果 Identifiler和PowerPlex 16两个系统所包含的17个亲权鉴定常用STR基因座在中国不同地区人群中的突变率无显著差异,合并计算其平均突变率介于0.0120%～0.2078%,不同STR基因座的平均突变率差异显著(P0.0001)。这17个亲权鉴定常用STR基因座在中国人群中的累积突变率达到1.9836%。结论本研究通过文献分析获得中国大样本人群的FGA等17个STR基因座突变率数据,对于疑似突变案例的累积亲权指数计算具有借鉴价值。
[Abstract]:Objective to estimate the average mutation rate of STR loci commonly used in paternity testing in Chinese population and compare it with the corresponding data in American population. Methods the mutation data were obtained from 15 domestic literatures selected according to the proposed criteria and the data of our center. The mutation data with no significant difference in the mutation rate of the same STR locus in different regions of China were combined to calculate the average mutation rate of the STR locus in Chinese population, and the 95% confidence interval of the average mutation rate of the STR locus was calculated by using the approximate normal distribution method of Poisson distribution. The 95% confidence interval of the average mutation rate of STR loci in Chinese and American populations was compared. Results there was no significant difference in the mutation rate of 17 STR loci commonly used in paternity testing between Identifiler and PowerPlex 16 systems in different regions of China. The average mutation rate was 0.0120% 鈮，
本文编号：2516765
[Abstract]:Objective to estimate the average mutation rate of STR loci commonly used in paternity testing in Chinese population and compare it with the corresponding data in American population. Methods the mutation data were obtained from 15 domestic literatures selected according to the proposed criteria and the data of our center. The mutation data with no significant difference in the mutation rate of the same STR locus in different regions of China were combined to calculate the average mutation rate of the STR locus in Chinese population, and the 95% confidence interval of the average mutation rate of the STR locus was calculated by using the approximate normal distribution method of Poisson distribution. The 95% confidence interval of the average mutation rate of STR loci in Chinese and American populations was compared. Results there was no significant difference in the mutation rate of 17 STR loci commonly used in paternity testing between Identifiler and PowerPlex 16 systems in different regions of China. The average mutation rate was 0.0120% 鈮，
本文编号：2516765
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