新生儿胎粪中邻苯二甲酸酯代谢物与脐带血激素水平的关联

发布时间：2018-03-05 06:27

本文选题：邻苯二甲酸酯类　切入点：胎粪　出处：《环境与职业医学》2017年04期 　论文类型：期刊论文

【摘要】：[目的]了解新生儿邻苯二甲酸酯(PAEs)宫内暴露的质量浓度(后称"浓度"),并探索其与新生儿性激素或甲状腺激素水平的关联。[方法]收集新生儿胎粪并检测胎粪中常见PAEs的代谢物,收集脐带血并检测游离睾酮(FT)、总四碘甲状腺素(T4)等常见性激素指标和甲状腺激素指标,并采用线性回归方法分析两者间的关系。[结果]新生儿胎粪中检出的代谢物主要是邻苯二甲酸单乙基己酯(MEHP)、邻苯二甲酸单正丁酯(Mn BP)和邻苯二甲酸单异丁酯(Mi BP),检出率分别为100%、99%和99%。男性新生儿雌二醇(E2)水平与邻苯二甲酸单甲酯(MMP)(b=2.44,P=0.027)、Mn BP(b=4.08,P=0.044)及Mi BP(b=3.89,P=0.003)呈正相关,FT与MEHP(b=4.42,P=0.049)呈正相关;女性新生儿性激素水平与各PAEs代谢物浓度未见关联。除男性促甲状腺激素(TSH)与邻苯二甲酸单乙酯(MEP)浓度(b=0.40,P=0.015)呈正相关外,新生儿甲状腺激素其余指标与PAEs浓度均未见关联。[结论]新生儿宫内暴露于PAEs与新生儿的性激素水平变化可能存在一定的关联。
[Abstract]:[objective] to investigate the concentration of intrauterine exposure ("concentration") of neonatal phthalate phthalate (PAEs) and to explore its association with neonatal sex hormone or thyroid hormone level. [methods] the meconium of newborn was collected and meconium was detected. Metabolites of PAEs, The common sex hormone and thyroid hormone indexes were collected from umbilical cord blood and free testosterone, total tetraiodothyronine (T4), and so on. [results] the main metabolites detected in meconium of newborns were monoethyl hexyl phthalate (MEHPN), n-butyl phthalate (n-butyl phthalate), and monobutyl phthalate (Mi BPN), and the main metabolites were monobutyl phthalate (Mi BPN), mono-butyl phthalate (Mi BPN), mono-butyl phthalate (Mi BPN) and mono-butyl phthalate (Mi BPN). The positive correlation was found between the levels of estradiol E _ (2) in male neonates and MMPP (2.44%) and Mi / B (3.89% P _ (0.003) P _ (0.044)) and MEHPB _ (4.42) P _ (0.049) in male neonates. The results showed that the positive correlation between the levels of estradiol E _ (2) in male neonates was positively correlated with that of MMPP (2.44) and Mi / B _ (3.89) (P _ (0.049)), and that there was a positive correlation between the levels of estradiol E _ (2) and MMPP _ (2.44). There was no correlation between sex hormone level and metabolite concentration of PAEs in female newborns, except for male thyroid stimulating hormone (TSH) and MEP concentration (0.40% P0. 015), there was a positive correlation between TSH and MEP concentration. There was no correlation between the other indexes of thyroid hormone and the concentration of PAEs. [conclusion] there may be some correlation between the changes of sex hormone level and intrauterine exposure to PAEs in neonates.
【作者单位】：同济大学附属第一妇婴保健院新生儿科;复旦大学公共卫生学院营养与食品卫生教研室教育部公共卫生安全重点实验室;
【基金】：国家自然科学基金项目(编号:81202208,81172673) 国家重点研发计划(编号:2016YFD0400602)
【分类号】：R722.1

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