制药行业挥发性有机物（VOCs）监测方法体系研究

发布时间：2018-03-29 01:37

本文选题：制药行业　切入点：监测方法体系　出处：《河北科技大学》2017年硕士论文

【摘要】：制药行业产品种类繁多,生产流程长、工艺复杂、原材料投入量大。许多原料和中间产物以废气形式排放到环境中,产生量大,成分复杂,危害严重。因此,如何建立适用于制药行业VOCs监测的方法体系是现如今的一个急需解决的问题。在本课题中,对现有制药行业VOCs的采样方法与监测分析方法进行了细致研究。首先,对制药企业排放的VOCs现有监测方法进行完善;其次,对尚没有监测方法的VOCs类物质尝试建立监测方法;最后,建立从简单到复杂的VOCs监测方法体系。主要内容主要包括以下几点:1)本次研究建立了完整的制药行业VOCs监测方法体系,首先采用手持式PID对VOCs总量进行快速监测,再用气质联机进行定性、定量全分析,最后利用气相色谱对其余特征污染物进行分析。2)建立了PID现场快速监测非甲烷烃的方法,可以实时出具数据,比现有的FID法简便、快捷,更适于现场直接监测,提高了监测效率。3)对利用气质联机定性和定量分析VOCs的方法予以改进,能够同时定性、定量的物质由EPA(TO-15)的64种增加到94种,并且增加的物质均为制药行业排放的污染物。4)本次研究列出包含毒性较大的物质的挥发性有机毒性污染物(VOTCs)清单,并建立了相应的VOTCs监测分析方法,采用当量加权毒性评价法评估制药行业VOCs的综合生物毒性。
[Abstract]:The pharmaceutical industry a wide range of products, the production process is long, complex process, large amount of raw material inputs. Many raw materials and intermediate products in the form of waste gas discharged into the environment, resulting in large quantity, complex composition, serious harm. Therefore, how to establish a system of methods applicable to the pharmaceutical industry VOCs monitoring is now an urgent need to solve now the problem. In this paper, the sampling method and monitoring analysis method of existing pharmaceutical industry VOCs was studied in detail. First, existing methods of monitoring VOCs for pharmaceutical enterprises to improve emissions; secondly, the VOCs material is no monitoring methods attempt to establish a monitoring method; finally, the establishment of monitoring method of VOCs system from simple to complex. The main contents include the following: 1) the study established a complete system of VOCs monitoring method for the pharmaceutical industry, the first handheld PID rapid monitoring of total amount of VOCs, and then Qualitative analysis was made using GC-MS, quantitative analysis, finally using gas chromatography to analyze.2 on the characteristics of pollutants was established on PID) rapid monitoring methods of non methane hydrocarbons, can be issued by the real-time data, than the existing FID method is simple, fast, more suitable for field monitoring, improve the monitoring efficiency of.3) by using GC-MS qualitative and quantitative analysis of VOCs can be improved, and the qualitative, quantitative material by EPA (TO-15) 64 increased to 94, and the increase of the material for the pharmaceutical industry.4 emissions of pollutants) on the list contains volatile organic pollutants toxic substances (VOTCs) list. And the establishment of a VOTCs method for the analysis of the corresponding monitoring, evaluation of the comprehensive assessment method of weighted equivalent toxicity of bio pharmaceutical industry VOCs toxicity.

【学位授予单位】：河北科技大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：X787;X831

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