基于胆酸分子两亲性的聚丙烯微孔膜表面改性

发布时间：2018-01-26 23:50

本文关键词： 胆酸聚丙烯微孔膜表面改性紫外光接枝溶剂响应性层层自组装　出处：《浙江大学》2015年硕士论文　论文类型：学位论文

【摘要】：胆酸是人和动物胆汁的主要成分,在人和动物体内发挥着重要的生理功能。由于胆酸分子特殊的面式双亲性、生物相容性、甾环稳定性、分子手性、分子自组装能力等诸多特性,以及胆酸上羟基和羧基的易修饰性,人们针对胆酸做了很多改性工作。其中包括基于胆酸的低聚物和高分子。然而目前研究者对胆酸在材料表面的改性工作缺乏必要的关注。本文主要考察胆酸对聚丙烯微孔膜表面的改性工作,分别提出了物理改性和化学改性两种修饰方法,测试了改性后聚丙烯微孔膜的相关性能,并探讨了胆酸改性膜的潜在应用。本文具体内容主要如下：化学改性方法首先通过紫外光接枝的方法在聚丙烯微孔膜表面构建聚甲基丙烯酸羟乙酯(poly(HEMA))高分子刷,然后通过N,N-二环已基碳二亚胺(DCC)和4-二甲胺基吡啶(DMAP)活化剂将胆酸化学反应到高分子刷上。物理改性方法则是将聚丙烯微孔膜浸泡在胆酸的四氢呋喃溶液中,胆酸直接物理吸附到微孔膜表面。ATR/FT-IR和XPS测试结果表明胆酸成功修饰到聚丙烯微孔膜表面。称重法测定了(poly(HEMA))高分子刷和胆酸的修饰量。考察了化学改性过程中HEMA单体浓度对接枝量的影响,物理改性过程中胆酸浓度和吸附时间对胆酸吸附量的影响。通过水接触角、场发射扫描电镜(FESEM)、荧光显微镜、固体荧光光谱以及水通量测试等表征了胆酸改性膜的性能。结果表明,胆酸高分子刷修饰的聚丙烯微孔膜具有溶剂响应性及选择性吸附的能力。另一方面,胆酸在聚丙烯微孔膜表面物理吸附时,能够发生层层自组装过程,吸附过程为多层吸附。水通量结果表明胆酸物理吸附的聚丙烯微孔膜的水通量也表现出同样的趋势。本文创新性的将胆酸引入到聚丙烯微孔膜表面,丰富了胆酸科学领域。构建了两种胆酸修饰聚丙烯微孔膜表明的方法,得到了溶剂响应性的微孔膜和层层自组装的微孔膜,拓展了聚丙烯微孔膜的应用范围。
[Abstract]:Cholic acid is the main component of bile in human and animal, and plays an important physiological function in human and animal. Because of its special surface amphiphilic, biocompatibility, steroid stability and chirality. The molecular self-assembly ability and many other properties, as well as the easy modification of hydroxyl and carboxyl groups on cholic acid. A lot of work has been done on the modification of cholic acid, including oligomers and polymers based on cholic acid. However, at present, researchers do not pay much attention to the modification of cholic acid on the surface of materials. In this paper, we mainly study the effect of cholic acid on polymer. Surface modification of propylene microporous membrane. Two modification methods, physical modification and chemical modification, were proposed, and the correlation properties of modified polypropylene microporous films were tested. The main contents of this paper are as follows: firstly, the chemical modification method was used to construct poly (hydroxyethyl methacrylate) on the surface of polypropylene microporous membrane. Hema brush. And then through N. N-Bicyclic hexyl carbodiimide (DCCs) and 4-dimethylaminopyridine (DMAP). The activator chemical reaction of cholic acid onto the polymer brush. The physical modification method is to immerse the polypropylene microporous membrane in the tetrahydrofuran solution of cholic acid. Direct physical adsorption of cholic acid onto the surface of microporous membrane. ATR / FT-IR and XPS results show that cholic acid has been successfully modified onto the surface of polypropylene microporous membrane. The influence of the concentration of HEMA monomer on the amount of graft in the process of chemical modification was investigated. The effects of cholic acid concentration and adsorption time on the adsorption capacity of cholic acid in the process of physical modification. Through water contact angle, field emission scanning electron microscope (SEM) and fluorescence microscope. The properties of the modified membranes were characterized by solid-state fluorescence spectra and water flux measurements. The results showed that the polymer brush modified polypropylene microporous membranes had the ability of solvent response and selective adsorption. Layer by layer self-assembly process occurs when cholic acid is physically adsorbed on the surface of polypropylene microporous membrane. The adsorption process is multilayer adsorption. The water flux results show that the water flux of polypropylene microporous membrane adsorbed by cholic acid shows the same trend. In this paper, the cholic acid was introduced into the surface of polypropylene microporous membrane. Two methods were constructed to show the modification of polypropylene microporous membrane by cholic acid. The solvent responsive microporous film and the layer by layer self-assembled microporous membrane were obtained. The application scope of polypropylene microporous membrane was expanded.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TQ325.14

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