改性聚柠檬酸酯的合成及其性能研究

发布时间：2018-06-17 06:11

本文选题：聚柠檬酸酯 + 改性　；参考：《哈尔滨理工大学》2015年硕士论文

【摘要】：柠檬酸酯类化合物是以柠檬酸为主要原料,具有无毒、生物降解性好、挥发性小、抗细菌等优点,是一种环境友好型材料。近年来,国内外对其的研究非常活跃,已成功开发出多种适合于不同领域的品种,前景广阔。本文首先采用柠檬酸、1,8-辛二醇为主要反应单体,分别以乙二醇、1,2-丙二醇、1,4-丁二醇和1,6-己二醇为改性剂,通过熔融聚合法合成一系列改性聚柠檬酸酯。然后,本文通过红外光谱(FTIR)、核磁共振(1H-NMR)、热重分析(TGA)、扫描电子显微镜(SEM)、亲水性能测试、溶胶及溶胀性能测试、吸水性测试及体外降解性能等测试对改性后的聚柠檬酸酯进行性能测试和表征。研究结果表明,改性聚柠檬酸酯是由溶胶和凝胶组成的,其中主要为凝胶,并且改性聚柠檬酸酯具有较好的热稳定性。随着改性剂含量的增加,聚柠檬酸酯的亲水性能、吸水性能和溶胀度随之增加;随着改性剂配比的增大,聚柠檬酸酯在PBS缓冲溶液中的降解速率逐渐增大。后聚合温度越高,聚柠檬酸酯的内部结构越紧密,溶胶含量越低,溶胀度越小,降解失重比越低。另外,本文采用物理共混的方法制备了载有药物扶他林的载药改性聚柠檬酸酯,并对其进行了药物释放性能研究。研究结果表明,载药聚柠檬酸酯的药物释放率随着载药量的增加而增大,药物的掺入并未对改性聚柠檬酸酯内部的分子链结构以及热性能产生明显影响,药物只是沉积到了改性聚柠檬酸酯表面并形成结晶。
[Abstract]:Citric acid esters are non-toxic, biodegradable, less volatile, anti-bacterial and so on. They are a kind of environment-friendly material. In recent years, the research on it has been very active at home and abroad, and it has successfully developed many varieties suitable for different fields. In this paper, a series of modified poly (citrate) esters were synthesized by melt polymerization with ethylene glycol (EG) 1 / 2 (2-propanediol) as modifier and hexanediol (1) 6 (hexanediol) as modifier. Then, FTIR, 1H-NMRT, TGA, SEM, hydrophilicity, sol-gel and swelling properties were measured. The properties of the modified polycitrate were tested and characterized by water absorption test and in vitro degradation test. The results show that the modified polycitrate is composed of sol and gel, mainly gel, and the modified polycitrate has good thermal stability. With the increase of the content of modifier, the hydrophilicity, water absorption and swelling degree of polycitrate increased, and the degradation rate of polycitrate in PBS buffer solution increased with the increase of the ratio of modifier. The higher the post-polymerization temperature, the closer the internal structure of the polycitrate, the lower the sol content, the smaller the swelling degree and the lower the weight loss ratio of degradation. In addition, the modified polycitrate containing the drug Fetalin was prepared by physical blending method and its drug release properties were studied. The results showed that the drug release rate of polycitrate increased with the increase of drug loading, and the incorporation of the drug had no obvious effect on the molecular chain structure and thermal properties of the modified polycitrate. The drug simply deposits onto the surface of the modified polycitrate and forms crystallization.
【学位授予单位】：哈尔滨理工大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TQ460.1

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