高强度与自修复水凝胶的制备与性能研究

发布时间：2019-01-21 07:58

【摘要】：由于具有优异的生物相容性,水凝胶在生物工程和组织工程等领域有着极其广泛的应用,高强度水凝胶更是由于其杰出的力学性能受到了研究人员的广泛关注。同时,考虑到能够在水凝胶在破裂时能够进行自修复以延长使用寿命,自修复水凝胶有着十分广泛的应用前景。在本文中,我们制备出具有自修复功能的高延展性水凝胶和双重物理交联的高强度水凝胶。本文的研究内容如下:(1)在第一章中我们简单介绍了不同类型的高强度水凝胶和自修复水凝胶。(2)在第二章中我们将两端乙烯基改性的普朗尼克F127(F127DA)与功能性单体N-丙烯酰基-6-氨基己酸(AACA)进行原位自由基共聚,得到具有自修复性能的高延展性水凝胶。在这个体系中,F127DA自组装成大分子胶束并作为多价交联剂均匀分散在水中。由于该水凝胶具有均匀的内部结构和有效的能量耗散机制,使其具有很高的延展性和耐穿刺性能。同时,由于聚合物的侧链十分柔软,能够在酸性条件下质子化并且穿过断裂面,与另一面聚合物的侧链形成强氢键作用,因此使水凝胶具有自修复性能。另外,由于单体N-丙烯酰基-6-氨基己酸(AACA)的pH响应性,使该水凝胶具有pH响应的循环溶胀-解溶胀性能。(3)在第三章中我们在水凝胶中同时引入F127DA大分子胶束的多价交联作用和Fe~(3+)-COO-配位络合交联作用,制备具有高强度、高韧性、高延展性和室温下可自回复的双物理交联水凝胶。F127DA大分子胶束的多价交联维持水凝胶的内在网络结构,三齿状Fe~(3+)-COO-动态络合能够在水凝胶拉伸过程中耗散大量能量,从而使水凝胶具有极佳的力学性能和回复性能。同时,该水凝胶还可以被赋予pH响应和氧化还原响应的形状记忆功能。
[Abstract]:Because of its excellent biocompatibility, hydrogel has been widely used in the fields of bioengineering and tissue engineering, and high strength hydrogel has been paid more and more attention by researchers because of its outstanding mechanical properties. At the same time, self-repairing hydrogels have a very wide application prospect considering that they can self-repair in order to prolong their service life when the hydrogels are ruptured. In this paper, we prepared high ductile hydrogels with self repairing function and high strength hydrogels with double physical crosslinking. The main contents of this paper are as follows: (1) in Chapter 1, we briefly introduce different types of high strength hydrogels and self-repair hydrogels. (2) in Chapter 2, we modify the vinyl ends of Plannick F127 (F127DA). In situ free radical copolymerization with functional monomer N-acryloyl-6-amino-caproic acid (AACA). High ductility hydrogels with self-repairing properties were obtained. In this system, F127DA self-assembled into macromolecular micelles and dispersed in water as a multivalent crosslinking agent. The hydrogel has high ductility and puncture resistance due to its uniform internal structure and effective energy dissipation mechanism. At the same time, because the side chain of the polymer is very soft, it can protonize under acidic condition and cross the fracture surface, forming strong hydrogen bond with the side chain of the other side polymer, so the hydrogel has self-repairing property. In addition, because of the pH responsiveness of monomer N-acryloyl-6-amino-caproic acid (AACA), The hydrogel has the properties of cyclic swelling and deswelling with pH response. (3) in chapter 3, we introduce the multivalent crosslinking of F127DA macromolecular micelles and the complexation crosslinking of Fe~ (3) -COO-. Bi-physical crosslinked hydrogels with high strength, toughness, ductility and self-recovery at room temperature were prepared. The polyvalent crosslinking of F127DA macromolecular micelles maintained the intrinsic network structure of hydrogels. Tridentate Fe~ (3)-COO- dynamic complexation can dissipate a lot of energy in the process of hydrogel stretching, which makes the hydrogel have excellent mechanical properties and recoverability. At the same time, the hydrogel can also be given shape memory function of pH response and redox response.
【学位授予单位】：中国科学技术大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TQ427.26

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