CTP结合醋甲唑胺试验对中、高海拔健康藏汉族脑血流储备能力的研究

发布时间：2017-12-26 17:20

本文关键词：CTP结合醋甲唑胺试验对中、高海拔健康藏汉族脑血流储备能力的研究　出处：《青海大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:利用CT灌注成像技术结合醋甲唑胺负荷试验,研究青海地区中、高海拔健康藏、汉族人群脑血流储备能力有无差异及脑血流储备能力与海拔高度的关系。方法:收集青海中、高海拔健康藏、汉族健康志愿者,共40例,男性,年龄30-45岁。使用GE Revolution CT机进行CT灌注成像(computed tomography perfusion,CTP)结合醋甲唑胺试验,获得灌注参数脑血流量(cerebral blood flow,CBF)、脑血容量(cerebral blood volume,CBV)和平均通过时间(mean transmit time,MTT),并计算脑血流储备值(cerebrovascular reserve,CVR)。使用SPSS21.0软件进行统计分析,计量资料用((?)±s)表示,激发试验前后灌注参数比较,采用配对t检验(α=0.01);中海拔藏、汉族,高海拔藏、汉族,中、高海拔藏族,中、高海拔汉族,组间CVR值两两比较,采用单因素方差分析(α=0.05)。结果:(1)激发试验前后灌注参数比较,激发试验后CBF、CBV升高,MTT缩短,除中海拔汉族颞叶和枕叶、高海拔汉族丘脑的CBV,中海拔藏族额叶、高海拔藏族颞叶和丘脑、中海拔藏汉族豆状核的MTT前后无显著性差异,其余感兴趣区(region of interest,ROI)灌注参数激发试验前后具有显著性差异。(2)中海拔藏、汉族CVR比较,额叶、颞叶、枕叶、豆状核、丘脑均无显著性差异;高海拔藏、汉族CVR比较,颞叶、豆状核具有显著性差异,藏族高于汉族。(3)中、高海拔藏族CVR比较,额叶、颞叶、枕叶、丘脑具有显著性差异,中、高海拔汉族CVR比较,额叶、丘脑具有显著性差异,高海拔高于中海拔。结论:(1)高海拔藏族脑血流储备能力高于中海拔藏族;(2)高海拔汉族脑血流储备能力高于中海拔汉族;(3)高海拔藏族脑血流储备能力高于汉族。
[Abstract]:Objective: combined with methazolamide stress test using CT perfusion imaging technology, research on the relationship between Qinghai area and high altitude healthy Tibetan and Han people have no difference of cerebrovascular reserve capacity and cerebral blood flow reserve capacity and altitude. Methods: a total of 40 healthy volunteers from the middle and high altitudes of Qinghai were collected, and the male was 30-45 years old. The use of GE Revolution CT CT perfusion imaging (computed tomography perfusion, CTP) combined with methazolamide test, obtained the cerebral blood flow perfusion parameters (cerebral blood, flow, CBF), cerebral blood volume (cerebral blood, volume, CBV) and the mean transit time (mean transmit, time, MTT), and calculate the value of cerebral blood flow reserve (cerebrovascular reserve CVR). SPSS21.0 software was used for statistical analysis, measurement data with ((?) + s) said that the perfusion parameters before and after the test excitation compared with paired t test (alpha =0.01); elevation of Tibetan and Han, Tibetan and Han in high altitude, high altitude, high altitude, Tibetan, Han, group CVR 22 compared with single factor analysis of variance (alpha =0.05). Results: (1) perfusion parameters before and after the test excitation, excitation test after CBF, CBV increased, MTT reduced, except in altitude Han temporal lobe and occipital lobe, thalamus in high altitude Han CBV, significant difference before and after the mid elevation Tibetan high altitude frontal lobe, temporal lobe and thalamus in Tibetan, Tibetan and Han pull lenticula MTT no, the rest of the region of interest (region of, interest, ROI) perfusion parameters before and after the provocation test with significant difference. (2) compared with CVR in Zhonghai and Tibet, there was no significant difference in frontal lobe, temporal lobe, occipital lobe, lenticular nucleus and thalamus. Compared with CVR in high altitude and Han nationality, there was significant difference between temporal lobe and lenticular nucleus, and Tibetan was higher than Han nationality. (3) compared with Tibetan Plateau CVR, there were significant differences in frontal lobe, temporal lobe, occipital lobe and thalamus. There was a significant difference between frontal lobe and thalamus in middle and high altitude Han CVR. Conclusion: (1) Gao Haiba Tibetan brain blood flow reserve capacity is higher than that of middle altitude Tibetans. (2) high altitude Han nationality has higher cerebral blood flow reserve capacity than the middle altitude Han nationality. (3) high altitude Tibetan brain blood flow reserve capacity is higher than Han nationality.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R816.1

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