抑郁症患者前瞻、回溯记忆及相关因素研究

发布时间：2017-12-27 02:05

本文关键词：抑郁症患者前瞻、回溯记忆及相关因素研究　出处：《山东大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:了解抑郁症患者前瞻、回溯记忆功能特征,并探讨其与焦虑、抑郁水平、炎性因子TNF-α等的相关性。方法:选取2016年1月--12月山东省某精神卫生机构收治的99名年龄在18-55岁之间的抑郁症患者,按照性别、年龄匹配的原则选择健康对照组99名,采用一般资料问卷、前瞻回溯记忆问卷(Prospective and RetrospectiveMemory Questionnaire,PRMQ)、病人健康问卷(patient health questionnaire,PHQ-9)和广泛性焦虑量表(7-tiem Generalized Anxiety Disorder Scale,GAD-7)进行调查。同时采集调查对象血液,采用放射免疫法检测血液中的炎性因子含量。结果:(1)患者组与健康对照组在性别、年龄、BMI和医疗费用类型等基本情况无统计学差异;(2)抑郁症患者组PRMQ总分为(39.39±16.76)分,范围18～77分,PM 得分(20.45±8.63),范围 8～40 分,RM 得分(18.94±8.41),范围 8～38分。经反向计分后,得分前三个条目为:①条目1:"你是否常在几分钟内决定做某件事情,但是随即遗忘",得分为(2.98±1.35)分;②条目11:"你是否在放下东西后随即遗忘位置,如手机或钥匙",得分为(2.96±1.32)分;③条目10:"你是否原本打算随身携带某样东西,但是转身即忘,即使东西就在眼前",得分为(2.88±1.24)分。对照组均分前三名为:条目1(2.85±1.14),条目10(2.76±0.92),条目11(2.61±1.04)。将两组的PRMQ总分及因子分进行比较,结果表明患者组的PRMQ总分及PM、RM因子分均比对照组高,但仅PM得分差异有统计学意义。(3)患者组对GAD-7、PHQ-9评估分数较对照组高,存在统计学差异。(4)运用独立样本t检验对两组的TNF-α、IL-1β、IL-6水平进行比对,结果显示,两组没有统计学差异。(5)PRMQ总分及因子分与GAD-7、PHQ-9评估分数正相关,r值0.48～0.59,有统计学意义。(6)PRMQ总分及因子分与TNF-α、IL-1β、IL-6的水平均无相关性。进一步对患者组、对照组分别进行偏相关分析发现,患者组的RM得分与IL-1β 呈负相关(r=-0.52,P=0.040)。结论:(1)抑郁症患者存有一定的前瞻、回溯记忆功能受损,前瞻记忆的受损较健康人严重。(2)焦虑和抑郁水平与前瞻、回溯记忆呈正相关关系,焦虑和抑郁水平越高,前瞻、回溯记忆损害越严重。(3)抑郁患者的回溯记忆与IL-1β水平呈负相关关系,较低的IL-1β水平与较严重的回溯记忆损害有关。
[Abstract]:Objective: To investigate the characteristics of prospective and retrospective memory function in patients with depression, and to explore the correlation with anxiety, depression level and inflammatory factor TNF- alpha. Methods: mental health institutions in Shandong Province in January 2016 --12 month from 99 aged 18-55 patients with depression, according to gender, age, the principle of selecting 99 healthy controls, using the general information questionnaire, prospective retrospective memory (Prospective and RetrospectiveMemory Questionnaire questionnaire, PRMQ), the patient health questionnaire (patient health questionnaire, PHQ-9) and generalized anxiety scale (7-tiem Generalized Anxiety Disorder Scale, GAD-7) were investigated. At the same time, the blood was collected and the content of inflammatory factors in the blood was detected by radioimmunoassay. Results: (1) patients group and healthy control group in the basic situation of gender, age, medical expenses and BMI type had no significant difference; (2) patients with depression group PRMQ score was (39.39 + 16.76) points, the range of 18 to 77 points, the score of PM (20.45 + 8.63), the range of 8 ~ 40. The RM score (18.94 + 8.41), the range of 8 ~ 38. The reverse after scoring three points, before entry: 1, item 1: "do you often within a few minutes to decide to do something, but then forgotten" score (2.98 + 1.35); the item 11: "if you put something in immediately after the forgotten position, such as a mobile phone or a key" score for (2.96 + 1.32); the item 10: "if you intend to carry something, but turned to forget, even if something is in sight," score (2.88 + 1.24) points. The first three in the control group were 1 (2.85 + 1.14), 10 (2.76 + 0.92), and 11 (2.61 + 1.04). The two groups of PRMQ total score and factor scores were compared. The results showed that the total score of PRMQ and the scores of PM and RM in the patients group were higher than those in the control group, but the difference in PM score was statistically significant. (3) the scores of GAD-7 and PHQ-9 in the patients group were higher than those in the control group, and there was a statistical difference. (4) using independent sample t test to compare the level of TNF- alpha, IL-1 beta and IL-6 in the two groups, the results showed that there was no statistical difference between the two groups. (5) the total score and factor score of PRMQ were positively correlated with the scores of GAD-7 and PHQ-9, and the value of R was 0.48 to 0.59, with statistical significance. (6) there was no correlation between the total score and the factor of PRMQ and the level of TNF- -, IL-1, and IL-6. The partial correlation analysis of the patient group and the control group showed that the RM score of the patient group was negatively correlated with the IL-1 beta (r=-0.52, P=0.040). Conclusion: (1) the patients with depression have some prospective and retrospective memory impairment, and the damage of prospective memory is more serious than that of the healthy people. (2) the level of anxiety and depression was positively related to prospective and backtracking memory, the higher the level of anxiety and depression, the more serious the prospective and retrospective memory impairment. (3) the backtracking memory of the depressive patients was negatively correlated with the level of IL-1 beta, and the lower IL-1 beta level was related to the more serious backtracking memory impairment.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R749.4

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