不同程度慢性阻塞性肺疾病稳定期患者血栓前状态的临床分析

发布时间：2017-12-28 18:44

本文关键词：不同程度慢性阻塞性肺疾病稳定期患者血栓前状态的临床分析　出处：《新疆医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨不同程度慢性阻塞性肺疾病稳定期患者血栓前状态的临床特点及意义。方法:选取符合纳入及排除标准的新疆医科大学第一附属医院收治的慢性阻塞性肺疾病150例患者,按照肺功能结果分为3组,即轻度组(n=50)、中度组(n=50)、重度及极重度组(n=50),同时随机选取50例我院健康体检者作为对照组(n=50)。比较分析各组患者的年龄、性别、民族等一般资料及凝血指标[纤维蛋白原(FIB)、活化的部分凝血活酶时间(APTT)、凝血酶原时间(PT)、D-二聚体(D-D)、血红蛋白(HB)、血小板计数(PLT)]的差异。结果:各组间年龄差异有统计学意义(F=2.859,P0.05),而性别及民族组间分布差异无统计学意义。轻度组、中度组、重度及极重度组与对照组的APTT(F=2.108,P0.05)、PLT(F=2.230,P0.05)、PT(F=2.487,P0.05)比较,差异无统计学意义。轻度组、中度组、重度及极重度组患者的HB(F=4.407,P0.05)、D-D(F=70.403,P0.05)、FIB(F=86.095,P0.05)与对照组比较,差异有统计学意义。轻度组与中度组、中度组与重度及极重度组、轻度组与重度及极重度组患者的HB(F=4.407,P0.05)、D-D(F=70.403,P0.05)、FIB(F=86.095,P0.05)比较,中度组高于轻度组,重度及极重度组高于中度组且明显高于轻度组,差异有统计学意义;而轻度组、中度组、重度组及极重度组间的APTT(F=2.108,P0.05)、PLT(F=2.230,P0.05)、PT(F=2.487,P0.05)比较结果差异无统计学意义。结论:不同程度的COPD稳定期患者血栓前状态存在差别。COPD病情程度越重,血栓前状态越显著。
[Abstract]:Objective: To explore the clinical features and significance of prethrombotic state in patients with chronic obstructive pulmonary disease at stable stage. Methods: selected 150 patients admitted to the inclusion and exclusion criteria, the First Affiliated Hospital of Xinjiang Medical University of chronic obstructive pulmonary disease, according to the pulmonary function were divided into 3 groups: mild group (n=50) group (n=50), moderate, severe and very severe group (n=50), and 50 healthy cases were selected with the machine I hospital as control group (n=50). A comparative analysis of each group of patients with general information and blood clotting index of age and gender and nationality [fibrinogen (FIB), activated partial thromboplastin time (APTT), prothrombin time (PT), two D- dimer (D-D), hemoglobin (HB), platelet count (PLT)] difference. Results: the age difference between each group was statistically significant (F=2.859, P0.05), but there was no significant difference in the distribution of sex and ethnic groups. There was no significant difference in APTT (F=2.108, P0.05), PLT (F=2.230, P0.05) and PT (F=2.487, P0.05) between mild group, moderate group, severe group and very severe group compared with control group. There were significant differences in HB (F=4.407, P0.05), D-D (F=70.403, P0.05) and FIB (F=86.095, P0.05) between mild group, moderate group, severe group and very severe group compared with control group. Mild group and moderate group, moderate group and severe and very severe group and mild group and severe and very severe patients with HB (F=4.407, P0.05), D-D (F=70.403, P0.05), FIB (F=86.095, P0.05), moderate group than in mild group, severe and very severe group was higher than the moderate group and was significantly higher than mild group, the difference was statistically significant; and mild group, moderate group and severe group and severe group of APTT (F=2.108, P0.05), PLT (F=2.230, P0.05), PT (F=2.487, P0.05) there was no significant difference in comparison. Conclusion: there is a difference in the prethrombotic state of patients with different degrees of COPD stability. The more severe the degree of COPD was, the more significant the prethrombotic state was.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.9

【相似文献】